The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior

Abstract Neurodevelopmental disorders are constantly increasing on a global scale. Some elements like heavy metals are known to be neurotoxic. In this cross-sectional study we assessed the neurobehavioral effect of the exposure to trace elements including lead, mercury, cadmium, manganese, arsenic a...

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Autores principales:	Stefano Renzetti, Giuseppa Cagna, Stefano Calza, Michele Conversano, Chiara Fedrighi, Giovanni Forte, Augusto Giorgino, Stefano Guazzetti, Costanza Majorani, Manuela Oppini, Marco Peli, Francesco Petrucci, Anna Pino, Donatella Placidi, Oreste Senofonte, Silvia Zoni, Alessandro Alimonti, Roberto G. Lucchini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90369180483544b5abb508086e7f5d6a
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spelling	oai:doaj.org-article:90369180483544b5abb508086e7f5d6a2021-12-02T14:35:34ZThe effects of the exposure to neurotoxic elements on Italian schoolchildren behavior10.1038/s41598-021-88969-z2045-2322https://doaj.org/article/90369180483544b5abb508086e7f5d6a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88969-zhttps://doaj.org/toc/2045-2322Abstract Neurodevelopmental disorders are constantly increasing on a global scale. Some elements like heavy metals are known to be neurotoxic. In this cross-sectional study we assessed the neurobehavioral effect of the exposure to trace elements including lead, mercury, cadmium, manganese, arsenic and selenium and their interactions among 299 schoolchildren residing in the heavily polluted Taranto area in Italy. Whole blood, urine and hair were collected for metal analyses, while the Child Behavior Checklist and the Social Responsiveness Scale, administered to the main teacher and the mothers were considered to identify behavioral problems in children. Blood lead mainly influenced social problems, aggressive behavior, externalizing and total problems. Urinary arsenic showed an impact on anxiety and depression, somatic problems, attention problems and rule breaking behavior. A significant interaction between lead and arsenic was observed, with a synergistic effect of the two metals increasing the risk of attention problems, aggressive behavior, externalizing problems and total problems. Overall, we were able to test that higher blood lead, urinary arsenic concentrations and their interaction increase the risk of neurobehavioral problems. This is in line with the U.S. Environmental Protection Agency’s priority list of hazardous substances where arsenic and lead are ranked as first and second respectively.Stefano RenzettiGiuseppa CagnaStefano CalzaMichele ConversanoChiara FedrighiGiovanni ForteAugusto GiorginoStefano GuazzettiCostanza MajoraniManuela OppiniMarco PeliFrancesco PetrucciAnna PinoDonatella PlacidiOreste SenofonteSilvia ZoniAlessandro AlimontiRoberto G. LucchiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Renzetti Giuseppa Cagna Stefano Calza Michele Conversano Chiara Fedrighi Giovanni Forte Augusto Giorgino Stefano Guazzetti Costanza Majorani Manuela Oppini Marco Peli Francesco Petrucci Anna Pino Donatella Placidi Oreste Senofonte Silvia Zoni Alessandro Alimonti Roberto G. Lucchini The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior
description	Abstract Neurodevelopmental disorders are constantly increasing on a global scale. Some elements like heavy metals are known to be neurotoxic. In this cross-sectional study we assessed the neurobehavioral effect of the exposure to trace elements including lead, mercury, cadmium, manganese, arsenic and selenium and their interactions among 299 schoolchildren residing in the heavily polluted Taranto area in Italy. Whole blood, urine and hair were collected for metal analyses, while the Child Behavior Checklist and the Social Responsiveness Scale, administered to the main teacher and the mothers were considered to identify behavioral problems in children. Blood lead mainly influenced social problems, aggressive behavior, externalizing and total problems. Urinary arsenic showed an impact on anxiety and depression, somatic problems, attention problems and rule breaking behavior. A significant interaction between lead and arsenic was observed, with a synergistic effect of the two metals increasing the risk of attention problems, aggressive behavior, externalizing problems and total problems. Overall, we were able to test that higher blood lead, urinary arsenic concentrations and their interaction increase the risk of neurobehavioral problems. This is in line with the U.S. Environmental Protection Agency’s priority list of hazardous substances where arsenic and lead are ranked as first and second respectively.
format	article
author	Stefano Renzetti Giuseppa Cagna Stefano Calza Michele Conversano Chiara Fedrighi Giovanni Forte Augusto Giorgino Stefano Guazzetti Costanza Majorani Manuela Oppini Marco Peli Francesco Petrucci Anna Pino Donatella Placidi Oreste Senofonte Silvia Zoni Alessandro Alimonti Roberto G. Lucchini
author_facet	Stefano Renzetti Giuseppa Cagna Stefano Calza Michele Conversano Chiara Fedrighi Giovanni Forte Augusto Giorgino Stefano Guazzetti Costanza Majorani Manuela Oppini Marco Peli Francesco Petrucci Anna Pino Donatella Placidi Oreste Senofonte Silvia Zoni Alessandro Alimonti Roberto G. Lucchini
author_sort	Stefano Renzetti
title	The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior
title_short	The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior
title_full	The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior
title_fullStr	The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior
title_full_unstemmed	The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior
title_sort	effects of the exposure to neurotoxic elements on italian schoolchildren behavior
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90369180483544b5abb508086e7f5d6a
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The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior

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