LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse...

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Autores principales:	James R. Bayrer, Hongtao Wang, Roy Nattiv, Miyuki Suzawa, Hazel S. Escusa, Robert J. Fletterick, Ophir D. Klein, David D. Moore, Holly A. Ingraham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90369e6a41a144aa93dc643e36748685
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spelling	oai:doaj.org-article:90369e6a41a144aa93dc643e367486852021-12-02T15:33:58ZLRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival10.1038/s41467-018-06137-w2041-1723https://doaj.org/article/90369e6a41a144aa93dc643e367486852018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06137-whttps://doaj.org/toc/2041-1723Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model.James R. BayrerHongtao WangRoy NattivMiyuki SuzawaHazel S. EscusaRobert J. FletterickOphir D. KleinDavid D. MooreHolly A. IngrahamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James R. Bayrer Hongtao Wang Roy Nattiv Miyuki Suzawa Hazel S. Escusa Robert J. Fletterick Ophir D. Klein David D. Moore Holly A. Ingraham LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
description	Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model.
format	article
author	James R. Bayrer Hongtao Wang Roy Nattiv Miyuki Suzawa Hazel S. Escusa Robert J. Fletterick Ophir D. Klein David D. Moore Holly A. Ingraham
author_facet	James R. Bayrer Hongtao Wang Roy Nattiv Miyuki Suzawa Hazel S. Escusa Robert J. Fletterick Ophir D. Klein David D. Moore Holly A. Ingraham
author_sort	James R. Bayrer
title	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
title_short	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
title_full	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
title_fullStr	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
title_full_unstemmed	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
title_sort	lrh-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/90369e6a41a144aa93dc643e36748685
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LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

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