Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion

Rosaria Del Giorno,1,2,* Christos Ceresa,1,* Sofia Gabutti,1 Chiara Troiani,1 Luca Gabutti1,2 1Department of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; 2Institute of Biomedicine, University of Southern Sw...

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Autores principales:	Del Giorno R, Ceresa C, Gabutti S, Troiani C, Gabutti L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	night-time urinary-sodium excretion day-time urinary-sodium excretion arterial stiffness pulse-wave velocity central hemodynamics central blood pressure. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/903a36de90d64a32b927af01f70369f0
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spelling	oai:doaj.org-article:903a36de90d64a32b927af01f70369f02021-12-02T11:27:31ZArterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion1178-7007https://doaj.org/article/903a36de90d64a32b927af01f70369f02020-09-01T00:00:00Zhttps://www.dovepress.com/arterial-stiffness-and-central-hemodynamics-are-associated-with-low-di-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Rosaria Del Giorno,1,2,* Christos Ceresa,1,* Sofia Gabutti,1 Chiara Troiani,1 Luca Gabutti1,2 1Department of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; 2Institute of Biomedicine, University of Southern Switzerland, Lugano, Switzerland*These authors contributed equally to this workCorrespondence: Rosaria Del Giorno; Luca GabuttiDepartment of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona 6500, Switzerland; Institute of Biomedicine, University of Southern Switzerland, Lugano, Switzerland Tel +41 91 811 94 08; +41 91 811 84 64Email rosaria.delgiorno@eoc.ch luca.gabutti@eoc.chBackground: Excessive salt intake is an important determinant of cardiovascular (CV) health, impacting arterial stiffness and central blood pressure. However, sodium exhibits several patterns of excretion in urine during day- and night-time, which could differently affect CV risk. Here, we sought to explore the relationship between the day:night urinary sodium excretion ratio and arterial stiffness and central hemodynamics in the general population.Methods: Cross-sectional analysis in 1062 subjects. Arterial stiffness (pulse-wave velocity, PWV), central blood pressure (central systolic blood pressure, cSBP; central diastolic blood pressure, cDBP), and other hemodynamic parameters were noninvasively assessed. Day- and night-time urinary sodium were separately detected. Analyses were performed according to the day:night urinary sodium excretion ratio tertiles (T1–T3).Results: Low day-time excretors (T1) showed significantly higher values of arterial stiffness when compared with high day-time excretors (T3) (cf-PWV 7.6 ± 1.9 vs 6.9 ± 1.5 m/sec; p ≤ 0.001), and higher central BP parameters (cSBP: 111.6 ± 12.1 vs 109.0 ± 11.1 mmHg, p ≤ 0.001; cDBP, 76.9 ± 9.2 vs 75.1 ± 9.3 mmHg, p ≤ 0.001). In multivariate linear-regression models (β, CI), the day:night ratio of sodium excretion was significantly associated with arterial stiffness (cf-PWV – 0.386, – 0.559, – 0.213, p ≤ 0.001) and with central hemodynamic parameters (cSBP – 1.655, – 2.800, – 0.510; p ≤ 0.001; cDBP – 1.319, – 2.218, – 0.420, p ≤ 0.001). Associations persisted after controlling for multiple confounding factors. In logistic-regression models, the risk of increased arterial stiffness was significantly reduced as the day:night ratio of urinary sodium excretion increased (OR 0.40, 95% CI 0.25– 0.65, p ≤ 0.001).Conclusion: The individual, intra-daily pattern of urinary sodium excretion, characterised by low daytime excretion, is associated with increased arterial stiffness and central blood pressure. Further studies are advocated to clarify the clinical utility of assessing the daily pattern of sodium excretion.Keywords: night-time urinary-sodium excretion, day-time urinary-sodium excretion, arterial stiffness, pulse-wave velocity, central hemodynamics, central blood pressureDel Giorno RCeresa CGabutti STroiani CGabutti LDove Medical Pressarticlenight-time urinary-sodium excretionday-time urinary-sodium excretionarterial stiffnesspulse-wave velocitycentral hemodynamicscentral blood pressure.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3289-3299 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	night-time urinary-sodium excretion day-time urinary-sodium excretion arterial stiffness pulse-wave velocity central hemodynamics central blood pressure. Specialties of internal medicine RC581-951
spellingShingle	night-time urinary-sodium excretion day-time urinary-sodium excretion arterial stiffness pulse-wave velocity central hemodynamics central blood pressure. Specialties of internal medicine RC581-951 Del Giorno R Ceresa C Gabutti S Troiani C Gabutti L Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion
description	Rosaria Del Giorno,1,2,* Christos Ceresa,1,* Sofia Gabutti,1 Chiara Troiani,1 Luca Gabutti1,2 1Department of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; 2Institute of Biomedicine, University of Southern Switzerland, Lugano, Switzerland*These authors contributed equally to this workCorrespondence: Rosaria Del Giorno; Luca GabuttiDepartment of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona 6500, Switzerland; Institute of Biomedicine, University of Southern Switzerland, Lugano, Switzerland Tel +41 91 811 94 08; +41 91 811 84 64Email rosaria.delgiorno@eoc.ch luca.gabutti@eoc.chBackground: Excessive salt intake is an important determinant of cardiovascular (CV) health, impacting arterial stiffness and central blood pressure. However, sodium exhibits several patterns of excretion in urine during day- and night-time, which could differently affect CV risk. Here, we sought to explore the relationship between the day:night urinary sodium excretion ratio and arterial stiffness and central hemodynamics in the general population.Methods: Cross-sectional analysis in 1062 subjects. Arterial stiffness (pulse-wave velocity, PWV), central blood pressure (central systolic blood pressure, cSBP; central diastolic blood pressure, cDBP), and other hemodynamic parameters were noninvasively assessed. Day- and night-time urinary sodium were separately detected. Analyses were performed according to the day:night urinary sodium excretion ratio tertiles (T1–T3).Results: Low day-time excretors (T1) showed significantly higher values of arterial stiffness when compared with high day-time excretors (T3) (cf-PWV 7.6 ± 1.9 vs 6.9 ± 1.5 m/sec; p ≤ 0.001), and higher central BP parameters (cSBP: 111.6 ± 12.1 vs 109.0 ± 11.1 mmHg, p ≤ 0.001; cDBP, 76.9 ± 9.2 vs 75.1 ± 9.3 mmHg, p ≤ 0.001). In multivariate linear-regression models (β, CI), the day:night ratio of sodium excretion was significantly associated with arterial stiffness (cf-PWV – 0.386, – 0.559, – 0.213, p ≤ 0.001) and with central hemodynamic parameters (cSBP – 1.655, – 2.800, – 0.510; p ≤ 0.001; cDBP – 1.319, – 2.218, – 0.420, p ≤ 0.001). Associations persisted after controlling for multiple confounding factors. In logistic-regression models, the risk of increased arterial stiffness was significantly reduced as the day:night ratio of urinary sodium excretion increased (OR 0.40, 95% CI 0.25– 0.65, p ≤ 0.001).Conclusion: The individual, intra-daily pattern of urinary sodium excretion, characterised by low daytime excretion, is associated with increased arterial stiffness and central blood pressure. Further studies are advocated to clarify the clinical utility of assessing the daily pattern of sodium excretion.Keywords: night-time urinary-sodium excretion, day-time urinary-sodium excretion, arterial stiffness, pulse-wave velocity, central hemodynamics, central blood pressure
format	article
author	Del Giorno R Ceresa C Gabutti S Troiani C Gabutti L
author_facet	Del Giorno R Ceresa C Gabutti S Troiani C Gabutti L
author_sort	Del Giorno R
title	Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion
title_short	Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion
title_full	Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion
title_fullStr	Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion
title_full_unstemmed	Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion
title_sort	arterial stiffness and central hemodynamics are associated with low diurnal urinary sodium excretion
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/903a36de90d64a32b927af01f70369f0
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Arterial Stiffness and Central Hemodynamics are Associated with Low Diurnal Urinary Sodium Excretion

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