Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)

Abstract To evaluate mosaic perfusion patterns and vascular lesions in patients with chronic thromboembolic pulmonary hypertension (CTEPH) using C-Arm computed tomography (CACT) compared to computed tomography pulmonary angiography (CTPA). We included 41 patients (18 female; mean age 59.9 ± 18.3 yea...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sabine K. Maschke, Thomas Werncke, Cornelia L. A. Dewald, Lena S. Becker, Timo C. Meine, Karen M. Olsson, Marius M. Hoeper, Frank K. Wacker, Bernhard C. Meyer, Jan B. Hinrichs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/903cc25d212749cdbe99e769b426adc0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:903cc25d212749cdbe99e769b426adc0
record_format	dspace
spelling	oai:doaj.org-article:903cc25d212749cdbe99e769b426adc02021-12-02T18:37:12ZDepiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)10.1038/s41598-021-99658-22045-2322https://doaj.org/article/903cc25d212749cdbe99e769b426adc02021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99658-2https://doaj.org/toc/2045-2322Abstract To evaluate mosaic perfusion patterns and vascular lesions in patients with chronic thromboembolic pulmonary hypertension (CTEPH) using C-Arm computed tomography (CACT) compared to computed tomography pulmonary angiography (CTPA). We included 41 patients (18 female; mean age 59.9 ± 18.3 years) with confirmed CTEPH who underwent CACT and CTPA within 21 days (average 5.3 ± 5.2). Two readers (R1; R2) independently evaluated datasets from both imaging techniques for mosaic perfusion patterns and presence of CTEPH-typical vascular lesions. The number of pulmonary arterial segments with typical findings was evaluated and the percentage of affected segments was calculated and categorized: < 25%; 25–49%; 50–75%; < 75% of all pulmonary arterial segments affected by thromboembolic vascular lesions. Inter-observer agreement was calculated for both modalities using the intraclass-correlation-coefficient (ICC). Based on consensus reading the inter-modality agreement (CACTcons vs. CTPAcons) was calculated using the ICC. Inter-observer agreement was excellent for central vascular lesions (ICC > 0.87) and the percentage of affected segments (ICC > 0.76) and good for the perceptibility of mosaic perfusion (ICC > 0.6) and attribution of the pattern of mosaic perfusion (ICC > 0.6) for both readers on CACT and CTPA. Inter-modality agreement was excellent for the perceptibility of mosaic perfusion (ICC = 1), the present perfusion pattern (ICC = 1) and central vascular lesions (ICC = 1). However, inter-modality agreement for the percentage of affected segments was fair (ICC = 0.50), with a greater proportion of identified affected segments on CACTcons. CACT demonstrates a high agreement with CTPA regarding the detection of mosaic perfusion. CACT detects a higher number of peripheral vascular lesions compared to CTPA.Sabine K. MaschkeThomas WernckeCornelia L. A. DewaldLena S. BeckerTimo C. MeineKaren M. OlssonMarius M. HoeperFrank K. WackerBernhard C. MeyerJan B. HinrichsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sabine K. Maschke Thomas Werncke Cornelia L. A. Dewald Lena S. Becker Timo C. Meine Karen M. Olsson Marius M. Hoeper Frank K. Wacker Bernhard C. Meyer Jan B. Hinrichs Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
description	Abstract To evaluate mosaic perfusion patterns and vascular lesions in patients with chronic thromboembolic pulmonary hypertension (CTEPH) using C-Arm computed tomography (CACT) compared to computed tomography pulmonary angiography (CTPA). We included 41 patients (18 female; mean age 59.9 ± 18.3 years) with confirmed CTEPH who underwent CACT and CTPA within 21 days (average 5.3 ± 5.2). Two readers (R1; R2) independently evaluated datasets from both imaging techniques for mosaic perfusion patterns and presence of CTEPH-typical vascular lesions. The number of pulmonary arterial segments with typical findings was evaluated and the percentage of affected segments was calculated and categorized: < 25%; 25–49%; 50–75%; < 75% of all pulmonary arterial segments affected by thromboembolic vascular lesions. Inter-observer agreement was calculated for both modalities using the intraclass-correlation-coefficient (ICC). Based on consensus reading the inter-modality agreement (CACTcons vs. CTPAcons) was calculated using the ICC. Inter-observer agreement was excellent for central vascular lesions (ICC > 0.87) and the percentage of affected segments (ICC > 0.76) and good for the perceptibility of mosaic perfusion (ICC > 0.6) and attribution of the pattern of mosaic perfusion (ICC > 0.6) for both readers on CACT and CTPA. Inter-modality agreement was excellent for the perceptibility of mosaic perfusion (ICC = 1), the present perfusion pattern (ICC = 1) and central vascular lesions (ICC = 1). However, inter-modality agreement for the percentage of affected segments was fair (ICC = 0.50), with a greater proportion of identified affected segments on CACTcons. CACT demonstrates a high agreement with CTPA regarding the detection of mosaic perfusion. CACT detects a higher number of peripheral vascular lesions compared to CTPA.
format	article
author	Sabine K. Maschke Thomas Werncke Cornelia L. A. Dewald Lena S. Becker Timo C. Meine Karen M. Olsson Marius M. Hoeper Frank K. Wacker Bernhard C. Meyer Jan B. Hinrichs
author_facet	Sabine K. Maschke Thomas Werncke Cornelia L. A. Dewald Lena S. Becker Timo C. Meine Karen M. Olsson Marius M. Hoeper Frank K. Wacker Bernhard C. Meyer Jan B. Hinrichs
author_sort	Sabine K. Maschke
title	Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
title_short	Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
title_full	Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
title_fullStr	Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
title_full_unstemmed	Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
title_sort	depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (cteph) on c-arm computed tomography compared to computed tomography pulmonary angiogram (ctpa)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/903cc25d212749cdbe99e769b426adc0
work_keys_str_mv	AT sabinekmaschke depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT thomaswerncke depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT cornelialadewald depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT lenasbecker depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT timocmeine depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT karenmolsson depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT mariusmhoeper depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT frankkwacker depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT bernhardcmeyer depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa AT janbhinrichs depictionofmosaicperfusioninchronicthromboembolicpulmonaryhypertensionctephoncarmcomputedtomographycomparedtocomputedtomographypulmonaryangiogramctpa
_version_	1718377811218006016

Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)

Ejemplares similares