Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model

Zika virus infection can cause severe disease in humans and there are currently no specific treatments or vaccines. Here, Bailey et al. isolate antibodies recognizing non-structural protein NS1 and show that they protect mice from disease by an Fc-dependent, non-neutralizing mechanism.

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Autores principales:	Mark J. Bailey, James Duehr, Harrison Dulin, Felix Broecker, Julia A. Brown, Fortuna O. Arumemi, Maria C. Bermúdez González, Victor H. Leyva-Grado, Matthew J. Evans, Viviana Simon, Jean K. Lim, Florian Krammer, Rong Hai, Peter Palese, Gene S. Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/903f1b10954c412ebb5d22ba6f570d2b
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spelling	oai:doaj.org-article:903f1b10954c412ebb5d22ba6f570d2b2021-12-02T16:49:55ZHuman antibodies targeting Zika virus NS1 provide protection against disease in a mouse model10.1038/s41467-018-07008-02041-1723https://doaj.org/article/903f1b10954c412ebb5d22ba6f570d2b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07008-0https://doaj.org/toc/2041-1723Zika virus infection can cause severe disease in humans and there are currently no specific treatments or vaccines. Here, Bailey et al. isolate antibodies recognizing non-structural protein NS1 and show that they protect mice from disease by an Fc-dependent, non-neutralizing mechanism.Mark J. BaileyJames DuehrHarrison DulinFelix BroeckerJulia A. BrownFortuna O. ArumemiMaria C. Bermúdez GonzálezVictor H. Leyva-GradoMatthew J. EvansViviana SimonJean K. LimFlorian KrammerRong HaiPeter PaleseGene S. TanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mark J. Bailey James Duehr Harrison Dulin Felix Broecker Julia A. Brown Fortuna O. Arumemi Maria C. Bermúdez González Victor H. Leyva-Grado Matthew J. Evans Viviana Simon Jean K. Lim Florian Krammer Rong Hai Peter Palese Gene S. Tan Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
description	Zika virus infection can cause severe disease in humans and there are currently no specific treatments or vaccines. Here, Bailey et al. isolate antibodies recognizing non-structural protein NS1 and show that they protect mice from disease by an Fc-dependent, non-neutralizing mechanism.
format	article
author	Mark J. Bailey James Duehr Harrison Dulin Felix Broecker Julia A. Brown Fortuna O. Arumemi Maria C. Bermúdez González Victor H. Leyva-Grado Matthew J. Evans Viviana Simon Jean K. Lim Florian Krammer Rong Hai Peter Palese Gene S. Tan
author_facet	Mark J. Bailey James Duehr Harrison Dulin Felix Broecker Julia A. Brown Fortuna O. Arumemi Maria C. Bermúdez González Victor H. Leyva-Grado Matthew J. Evans Viviana Simon Jean K. Lim Florian Krammer Rong Hai Peter Palese Gene S. Tan
author_sort	Mark J. Bailey
title	Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
title_short	Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
title_full	Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
title_fullStr	Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
title_full_unstemmed	Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
title_sort	human antibodies targeting zika virus ns1 provide protection against disease in a mouse model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/903f1b10954c412ebb5d22ba6f570d2b
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Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model

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