Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study

Levothyroxine (LT4) is a standard therapy in hypothyroidism; however, its bioavailability and therapeutic effects might be affected by many factors. Data shows that therapy with liquid LT4 characterized by quicker pharmacokinetics provides better thyroid hormones control than tablet LT4. We addresse...

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Autores principales:	Katarzyna Bornikowska, Małgorzata Gietka-Czernel, Dorota Raczkiewicz, Piotr Glinicki, Wojciech Zgliczyński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	liquid levothyroxine hypothyroidism quality of life questionnaire ThyPROpl sex hormone binding globulin Medicine R
Acceso en línea:	https://doaj.org/article/903fdb55d0734ed9b771380b5690e44b
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spelling	oai:doaj.org-article:903fdb55d0734ed9b771380b5690e44b2021-11-25T18:00:43ZImprovements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study10.3390/jcm102252332077-0383https://doaj.org/article/903fdb55d0734ed9b771380b5690e44b2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5233https://doaj.org/toc/2077-0383Levothyroxine (LT4) is a standard therapy in hypothyroidism; however, its bioavailability and therapeutic effects might be affected by many factors. Data shows that therapy with liquid LT4 characterized by quicker pharmacokinetics provides better thyroid hormones control than tablet LT4. We addressed the quality of life (QoL) and efficacy of the new ethanol-free formula of liquid LT4 (Tirosint<sup>®</sup>SOL) treatment in 76 euthyroid patients with primary (PH, <i>n</i> = 46) and central hypothyroidism (CH, <i>n</i> = 30), and compared the results to retrospective data on equivalent doses of tablet L-T4 therapy. After 8 weeks of liquid LT4 therapy, we found a significant improvement in QoL in both PH and CH patients. TSH levels were unaltered in PH patients. Free hormone levels (fT4 and fT3) increased in all the patients, with the exception of fT3 in the CH group. SHBG and low-density lipoprotein (LDL) also improved. Liquid LT4 therapy provided a better thyroid hormone profile and improvement in patients’ QoL than the tablet form, which was possibly due to the more favorable pharmacokinetics profile resulting in better absorption, as suggested by the increased free thyroid hormone levels. In summary, this is the first study addressing the QoL in hypothyroid patients, including primary and central hypothyroidism, treated with liquid LT4 formula in everyday practice.Katarzyna BornikowskaMałgorzata Gietka-CzernelDorota RaczkiewiczPiotr GlinickiWojciech ZgliczyńskiMDPI AGarticleliquid levothyroxinehypothyroidismquality of lifequestionnaire ThyPROplsex hormone binding globulinMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5233, p 5233 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liquid levothyroxine hypothyroidism quality of life questionnaire ThyPROpl sex hormone binding globulin Medicine R
spellingShingle	liquid levothyroxine hypothyroidism quality of life questionnaire ThyPROpl sex hormone binding globulin Medicine R Katarzyna Bornikowska Małgorzata Gietka-Czernel Dorota Raczkiewicz Piotr Glinicki Wojciech Zgliczyński Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study
description	Levothyroxine (LT4) is a standard therapy in hypothyroidism; however, its bioavailability and therapeutic effects might be affected by many factors. Data shows that therapy with liquid LT4 characterized by quicker pharmacokinetics provides better thyroid hormones control than tablet LT4. We addressed the quality of life (QoL) and efficacy of the new ethanol-free formula of liquid LT4 (Tirosint<sup>®</sup>SOL) treatment in 76 euthyroid patients with primary (PH, <i>n</i> = 46) and central hypothyroidism (CH, <i>n</i> = 30), and compared the results to retrospective data on equivalent doses of tablet L-T4 therapy. After 8 weeks of liquid LT4 therapy, we found a significant improvement in QoL in both PH and CH patients. TSH levels were unaltered in PH patients. Free hormone levels (fT4 and fT3) increased in all the patients, with the exception of fT3 in the CH group. SHBG and low-density lipoprotein (LDL) also improved. Liquid LT4 therapy provided a better thyroid hormone profile and improvement in patients’ QoL than the tablet form, which was possibly due to the more favorable pharmacokinetics profile resulting in better absorption, as suggested by the increased free thyroid hormone levels. In summary, this is the first study addressing the QoL in hypothyroid patients, including primary and central hypothyroidism, treated with liquid LT4 formula in everyday practice.
format	article
author	Katarzyna Bornikowska Małgorzata Gietka-Czernel Dorota Raczkiewicz Piotr Glinicki Wojciech Zgliczyński
author_facet	Katarzyna Bornikowska Małgorzata Gietka-Czernel Dorota Raczkiewicz Piotr Glinicki Wojciech Zgliczyński
author_sort	Katarzyna Bornikowska
title	Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study
title_short	Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study
title_full	Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study
title_fullStr	Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study
title_full_unstemmed	Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study
title_sort	improvements in quality of life and thyroid parameters in hypothyroid patients on ethanol-free formula of liquid levothyroxine therapy in comparison to tablet lt4 form: an observational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/903fdb55d0734ed9b771380b5690e44b
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Improvements in Quality of Life and Thyroid Parameters in Hypothyroid Patients on Ethanol-Free Formula of Liquid Levothyroxine Therapy in Comparison to Tablet LT4 Form: An Observational Study

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