Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi

Abstract Background Mississippi (MS) has among the highest rates of cervical cancer incidence and mortality in the United States, with disproportionately higher rates among Blacks compared to Whites. Here, we evaluate the prevalence of high‐risk human papillomavirus (HPV) and abnormal cytology in a...

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Autores principales:	Megan A. Clarke, Carolann Risley, Mary W. Stewart, Kim R. Geisinger, Laree M. Hiser, Jody C. Morgan, Kenyata J. Owens, Krishna Ayyalasomayajula, Rhonda M. Rives, Ashish Jannela, Dianne E. Grunes, Lei Zhang, Mark Schiffman, Sarah Wagner, Joseph Boland, Sara Bass, Nicolas Wentzensen
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cervical cancer human papillomavirus Mississippi natural history racial differences Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/90411cc7167047ea9ce074f01ddcdbcc
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spelling	oai:doaj.org-article:90411cc7167047ea9ce074f01ddcdbcc2021-12-01T04:49:16ZAge‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi2045-763410.1002/cam4.4340https://doaj.org/article/90411cc7167047ea9ce074f01ddcdbcc2021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4340https://doaj.org/toc/2045-7634Abstract Background Mississippi (MS) has among the highest rates of cervical cancer incidence and mortality in the United States, with disproportionately higher rates among Blacks compared to Whites. Here, we evaluate the prevalence of high‐risk human papillomavirus (HPV) and abnormal cytology in a representative baseline sample from a diverse statewide cohort of individuals attending cervical screening in MS from the STRIDES Study (STudying Risk to Improve DisparitiES in cervical cancer). Methods We included individuals aged 21–65 years undergoing screening at the University of Mississippi Medical Center (UMMC) and the Mississippi State Department of Health (MSDH) from May to November 2018. We calculated age‐specific HPV prevalence, overall and by partial HPV16/18 genotyping, and abnormal cytology by race. Results A total of 6871 individuals (mean age 35.7 years) were included. HPV prevalence was 25.6% and higher in Blacks (28.0%) compared to Whites (22.4%). HPV prevalence was significantly higher in Blacks aged 21–24 years (50.2%) and 30–34 years (30.2%) compared to Whites in the same age groups (32.1% and 20.7%; p < 0.0001, respectively). The prevalence of high‐grade cytologic abnormalities, a cytologic sign of cervical precancer, peaked earlier in Blacks (ages 25–29) compared to Whites (35–39). For comparison, we also analyzed HPV prevalence data from the National Health and Nutrition Examination Survey (NHANES, 2013–2016) and observed similar racial differences in HPV prevalence among women aged 21–24 years. Conclusions Our findings suggest that Blacks undergoing cervical cancer screening in MS have higher prevalence of other high‐risk 12 HPV types at younger ages and experience an earlier peak of high‐grade cytologic abnormalities compared to Whites.Megan A. ClarkeCarolann RisleyMary W. StewartKim R. GeisingerLaree M. HiserJody C. MorganKenyata J. OwensKrishna AyyalasomayajulaRhonda M. RivesAshish JannelaDianne E. GrunesLei ZhangMark SchiffmanSarah WagnerJoseph BolandSara BassNicolas WentzensenWileyarticlecervical cancerhuman papillomavirusMississippinatural historyracial differencesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8641-8650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer human papillomavirus Mississippi natural history racial differences Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cervical cancer human papillomavirus Mississippi natural history racial differences Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Megan A. Clarke Carolann Risley Mary W. Stewart Kim R. Geisinger Laree M. Hiser Jody C. Morgan Kenyata J. Owens Krishna Ayyalasomayajula Rhonda M. Rives Ashish Jannela Dianne E. Grunes Lei Zhang Mark Schiffman Sarah Wagner Joseph Boland Sara Bass Nicolas Wentzensen Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
description	Abstract Background Mississippi (MS) has among the highest rates of cervical cancer incidence and mortality in the United States, with disproportionately higher rates among Blacks compared to Whites. Here, we evaluate the prevalence of high‐risk human papillomavirus (HPV) and abnormal cytology in a representative baseline sample from a diverse statewide cohort of individuals attending cervical screening in MS from the STRIDES Study (STudying Risk to Improve DisparitiES in cervical cancer). Methods We included individuals aged 21–65 years undergoing screening at the University of Mississippi Medical Center (UMMC) and the Mississippi State Department of Health (MSDH) from May to November 2018. We calculated age‐specific HPV prevalence, overall and by partial HPV16/18 genotyping, and abnormal cytology by race. Results A total of 6871 individuals (mean age 35.7 years) were included. HPV prevalence was 25.6% and higher in Blacks (28.0%) compared to Whites (22.4%). HPV prevalence was significantly higher in Blacks aged 21–24 years (50.2%) and 30–34 years (30.2%) compared to Whites in the same age groups (32.1% and 20.7%; p < 0.0001, respectively). The prevalence of high‐grade cytologic abnormalities, a cytologic sign of cervical precancer, peaked earlier in Blacks (ages 25–29) compared to Whites (35–39). For comparison, we also analyzed HPV prevalence data from the National Health and Nutrition Examination Survey (NHANES, 2013–2016) and observed similar racial differences in HPV prevalence among women aged 21–24 years. Conclusions Our findings suggest that Blacks undergoing cervical cancer screening in MS have higher prevalence of other high‐risk 12 HPV types at younger ages and experience an earlier peak of high‐grade cytologic abnormalities compared to Whites.
format	article
author	Megan A. Clarke Carolann Risley Mary W. Stewart Kim R. Geisinger Laree M. Hiser Jody C. Morgan Kenyata J. Owens Krishna Ayyalasomayajula Rhonda M. Rives Ashish Jannela Dianne E. Grunes Lei Zhang Mark Schiffman Sarah Wagner Joseph Boland Sara Bass Nicolas Wentzensen
author_facet	Megan A. Clarke Carolann Risley Mary W. Stewart Kim R. Geisinger Laree M. Hiser Jody C. Morgan Kenyata J. Owens Krishna Ayyalasomayajula Rhonda M. Rives Ashish Jannela Dianne E. Grunes Lei Zhang Mark Schiffman Sarah Wagner Joseph Boland Sara Bass Nicolas Wentzensen
author_sort	Megan A. Clarke
title	Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
title_short	Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
title_full	Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
title_fullStr	Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
title_full_unstemmed	Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
title_sort	age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in mississippi
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/90411cc7167047ea9ce074f01ddcdbcc
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Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi

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