Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?

Rebecca Perrain,1,2 David Calvet,3– 5 Vincent Guiraud,3– 5 Lila Mekaoui,1 Jean-Louis Mas,3– 5 Philip Gorwood1,2,5 1GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris, France; 2University of Paris, Paris, France; 3GHU Paris Psychiatrie et...

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Autores principales:	Perrain R, Calvet D, Guiraud V, Mekaoui L, Mas JL, Gorwood P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	post-stroke depression depression stroke risk factors prevention cohort Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9043c116d9534a438e11352fc1fc4236
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spelling	oai:doaj.org-article:9043c116d9534a438e11352fc1fc42362021-12-02T14:51:56ZDepressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?1178-2021https://doaj.org/article/9043c116d9534a438e11352fc1fc42362021-04-01T00:00:00Zhttps://www.dovepress.com/depressive--cognitive--or-stroke-related-risk-factors-of-post-stroke-d-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Rebecca Perrain,1,2 David Calvet,3– 5 Vincent Guiraud,3– 5 Lila Mekaoui,1 Jean-Louis Mas,3– 5 Philip Gorwood1,2,5 1GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris, France; 2University of Paris, Paris, France; 3GHU Paris Psychiatrie et Neurosciences, Department of Neurology, Hôpital Sainte-Anne, Paris, France; 4University of Paris, FHU Neurovasc, Paris, France; 5Institute of Psychiatry and Neuroscience of Paris, INSERMU1266, Paris, FranceCorrespondence: Rebecca PerrainClinique des Maladies Mentales et de l’Encéphale, Sainte-Anne Hospital, GHU Paris– Psychiatrie & Neurosciences, 100 rue de la Santé 75674 Paris Cedex 14, Paris, FranceTel +33 1 45 65 83 64Fax +33 1 45 65 76 56Email r.perrain@ghu-paris.frPurpose: Post-stroke depression (PSD) affects one third of stroke survivors, with multiple severe negative consequences. We aim to assess the weight of four different types of clinical risk factors for PSD.Patients and Methods: We conducted a prospective cohort study in a stroke centre. After stroke, patients were assessed for cognitive performances, psychiatric standardized questionnaires and socio-demographic features. They were called three months after and assessed for major depressive episode using DSM criteria.Results: PSD was diagnosed in 8 of the 59 (13.6%) patients enrolled in the study. After multivariate analysis, only “previous history of depressive episode” remained a significant predictive factor for PSD, the model explaining 19% of the total variance (OR=18.0; p=0.002). Patients with a previous history of depression had a 10-fold increased risk for PSD.Conclusion: Previous history of depression is confirmed as a strong risk factor for PDS and allow the identification of an at-risk sub-group of patients.Keywords: post-stroke depression, depression, stroke, risk factors, prevention, cohortPerrain RCalvet DGuiraud VMekaoui LMas JLGorwood PDove Medical Pressarticlepost-stroke depressiondepressionstrokerisk factorspreventioncohortNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1243-1251 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-stroke depression depression stroke risk factors prevention cohort Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	post-stroke depression depression stroke risk factors prevention cohort Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Perrain R Calvet D Guiraud V Mekaoui L Mas JL Gorwood P Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
description	Rebecca Perrain,1,2 David Calvet,3– 5 Vincent Guiraud,3– 5 Lila Mekaoui,1 Jean-Louis Mas,3– 5 Philip Gorwood1,2,5 1GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris, France; 2University of Paris, Paris, France; 3GHU Paris Psychiatrie et Neurosciences, Department of Neurology, Hôpital Sainte-Anne, Paris, France; 4University of Paris, FHU Neurovasc, Paris, France; 5Institute of Psychiatry and Neuroscience of Paris, INSERMU1266, Paris, FranceCorrespondence: Rebecca PerrainClinique des Maladies Mentales et de l’Encéphale, Sainte-Anne Hospital, GHU Paris– Psychiatrie & Neurosciences, 100 rue de la Santé 75674 Paris Cedex 14, Paris, FranceTel +33 1 45 65 83 64Fax +33 1 45 65 76 56Email r.perrain@ghu-paris.frPurpose: Post-stroke depression (PSD) affects one third of stroke survivors, with multiple severe negative consequences. We aim to assess the weight of four different types of clinical risk factors for PSD.Patients and Methods: We conducted a prospective cohort study in a stroke centre. After stroke, patients were assessed for cognitive performances, psychiatric standardized questionnaires and socio-demographic features. They were called three months after and assessed for major depressive episode using DSM criteria.Results: PSD was diagnosed in 8 of the 59 (13.6%) patients enrolled in the study. After multivariate analysis, only “previous history of depressive episode” remained a significant predictive factor for PSD, the model explaining 19% of the total variance (OR=18.0; p=0.002). Patients with a previous history of depression had a 10-fold increased risk for PSD.Conclusion: Previous history of depression is confirmed as a strong risk factor for PDS and allow the identification of an at-risk sub-group of patients.Keywords: post-stroke depression, depression, stroke, risk factors, prevention, cohort
format	article
author	Perrain R Calvet D Guiraud V Mekaoui L Mas JL Gorwood P
author_facet	Perrain R Calvet D Guiraud V Mekaoui L Mas JL Gorwood P
author_sort	Perrain R
title	Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
title_short	Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
title_full	Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
title_fullStr	Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
title_full_unstemmed	Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
title_sort	depressive-, cognitive- or stroke-related risk factors of post-stroke depression: which one could better help clinicians and patients?
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9043c116d9534a438e11352fc1fc4236
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Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?

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