Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases

John Carmody1, Raghunath P Misra1,2, Marlyn P Langford1, William A Byrd1, Lauren Ditta1, Bryan Vekovius1, Donald E Texada11Department of Ophthalmology, 2Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USAAbstract: A case of sporadic Burkitt lymphoma (sBL)...

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Autores principales:	Carmody J, Misra RP, Langford MP, Byrd WA, Ditta L, Vekovius B, Texada DE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/90470ab7dadd4cbca575fc44ed548d97
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spelling	oai:doaj.org-article:90470ab7dadd4cbca575fc44ed548d972021-12-02T03:43:13ZOrbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases1177-54671177-5483https://doaj.org/article/90470ab7dadd4cbca575fc44ed548d972011-04-01T00:00:00Zhttp://www.dovepress.com/orbital-sporadic-burkitt-lymphoma-in-an-adult-diabetic-african-america-a7195https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483John Carmody1, Raghunath P Misra1,2, Marlyn P Langford1, William A Byrd1, Lauren Ditta1, Bryan Vekovius1, Donald E Texada11Department of Ophthalmology, 2Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USAAbstract: A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a &quot;starry sky&quot; appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein&ndash;Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.Keywords: B-cells, Burkitt lymphoma, cancer, diabetes, eye, Epstein&ndash;Barr virus, orbit, tumor Carmody JMisra RPLangford MPByrd WADitta LVekovius BTexada DEDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 509-515 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Carmody J Misra RP Langford MP Byrd WA Ditta L Vekovius B Texada DE Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
description	John Carmody1, Raghunath P Misra1,2, Marlyn P Langford1, William A Byrd1, Lauren Ditta1, Bryan Vekovius1, Donald E Texada11Department of Ophthalmology, 2Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USAAbstract: A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a &quot;starry sky&quot; appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein&ndash;Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.Keywords: B-cells, Burkitt lymphoma, cancer, diabetes, eye, Epstein&ndash;Barr virus, orbit, tumor
format	article
author	Carmody J Misra RP Langford MP Byrd WA Ditta L Vekovius B Texada DE
author_facet	Carmody J Misra RP Langford MP Byrd WA Ditta L Vekovius B Texada DE
author_sort	Carmody J
title	Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
title_short	Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
title_full	Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
title_fullStr	Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
title_full_unstemmed	Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
title_sort	orbital sporadic burkitt lymphoma in an adult diabetic african american female and a review of adult orbital cases
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/90470ab7dadd4cbca575fc44ed548d97
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Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases

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