Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.

<h4>Background & aims</h4>Fatty liver is associated with incident diabetes, and the fatty liver index (FLI) is a surrogate marker for non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether or not FLI was associated with incident diabetes in relation to obesity and p...

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Autores principales:	Atsushi Kitazawa, Shotaro Maeda, Yoshiharu Fukuda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/904a5ddd70154ba68b311894c97c8ee2
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spelling	oai:doaj.org-article:904a5ddd70154ba68b311894c97c8ee22021-12-02T20:06:12ZFatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.1932-620310.1371/journal.pone.0257352https://doaj.org/article/904a5ddd70154ba68b311894c97c8ee22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257352https://doaj.org/toc/1932-6203<h4>Background & aims</h4>Fatty liver is associated with incident diabetes, and the fatty liver index (FLI) is a surrogate marker for non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether or not FLI was associated with incident diabetes in relation to obesity and prediabetic levels in the general Japanese population.<h4>Methods</h4>This was a retrospective study using the Japanese health check-up database of one health insurance from FY2015 to FY2018. This study included 28,991 individuals with prediabetes. First, we stratified all participants into two groups: "high-risk," comprising patients with HbA1c >6.0%, and "standard," comprising the rest. Subsequently, we divided them into four groups according to FLI (<30 or not) and obesity (BMI <25 kg/m2 or not). Subsequently, the incidence rate of diabetes was compared among the groups after 3 years of follow-up using multiple logistic regression models after adjusting for potential confounders.<h4>Results</h4>After 3 years of follow-up, 1,547 new cases of diabetes were found, and the cumulative incidence was 2.96% for the standard group and 26.1% for the high-risk group. In non-obese individuals, odds ratios (95% confidence interval) for FLI ≥30 versus FLI <30 were: 1.44 (1.09-1.92) for the standard group and 1.42 (0.99-2.03) for the high-risk group. In the high-risk group, obesity (BMI ≥25 kg/m2) but FLI <30 was not a risk factor for developing diabetes.<h4>Conclusion</h4>Although high FLI is generally considered to be a risk factor for developing diabetes, obesity might have been a confounding factor. However, the present study showed that high FLI is a risk factor for the development of diabetes, even in non-obese individuals. Our results include suggestion to develop a screening tool to effectively identify people at high risk of developing diabetes from the population (especially non-obese prediabetes) who are apparently at low health risk and are unlikely to be targeted for health guidance.Atsushi KitazawaShotaro MaedaYoshiharu FukudaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257352 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsushi Kitazawa Shotaro Maeda Yoshiharu Fukuda Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
description	<h4>Background & aims</h4>Fatty liver is associated with incident diabetes, and the fatty liver index (FLI) is a surrogate marker for non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether or not FLI was associated with incident diabetes in relation to obesity and prediabetic levels in the general Japanese population.<h4>Methods</h4>This was a retrospective study using the Japanese health check-up database of one health insurance from FY2015 to FY2018. This study included 28,991 individuals with prediabetes. First, we stratified all participants into two groups: "high-risk," comprising patients with HbA1c >6.0%, and "standard," comprising the rest. Subsequently, we divided them into four groups according to FLI (<30 or not) and obesity (BMI <25 kg/m2 or not). Subsequently, the incidence rate of diabetes was compared among the groups after 3 years of follow-up using multiple logistic regression models after adjusting for potential confounders.<h4>Results</h4>After 3 years of follow-up, 1,547 new cases of diabetes were found, and the cumulative incidence was 2.96% for the standard group and 26.1% for the high-risk group. In non-obese individuals, odds ratios (95% confidence interval) for FLI ≥30 versus FLI <30 were: 1.44 (1.09-1.92) for the standard group and 1.42 (0.99-2.03) for the high-risk group. In the high-risk group, obesity (BMI ≥25 kg/m2) but FLI <30 was not a risk factor for developing diabetes.<h4>Conclusion</h4>Although high FLI is generally considered to be a risk factor for developing diabetes, obesity might have been a confounding factor. However, the present study showed that high FLI is a risk factor for the development of diabetes, even in non-obese individuals. Our results include suggestion to develop a screening tool to effectively identify people at high risk of developing diabetes from the population (especially non-obese prediabetes) who are apparently at low health risk and are unlikely to be targeted for health guidance.
format	article
author	Atsushi Kitazawa Shotaro Maeda Yoshiharu Fukuda
author_facet	Atsushi Kitazawa Shotaro Maeda Yoshiharu Fukuda
author_sort	Atsushi Kitazawa
title	Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
title_short	Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
title_full	Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
title_fullStr	Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
title_full_unstemmed	Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.
title_sort	fatty liver index as a predictive marker for the development of diabetes: a retrospective cohort study using japanese health check-up data.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/904a5ddd70154ba68b311894c97c8ee2
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Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data.

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