Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses

Gangfeng Hu,1,2 Hui Wang,1 Xiaocong Yao,1 Dawei Bi,1 Gang Zhu,1 Songchao Tang,2 Jie Wei,2 Lili Yang,3 Peijian Tong,4 Luwei Xiao4 1The First People’s Hospital of Xiaoshang, Hangzhou, People’s Republic of China; 2Key Laboratory of Ultra-fine Materials, Ministry of Education, East...

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Autores principales:	Hu G, Wang H, Yao X, Bi D, Zhu G, Tang S, Wei J, Yang L, Tong P, Xiao L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/904be59b28824dbb8a258504bab4203e
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spelling	oai:doaj.org-article:904be59b28824dbb8a258504bab4203e2021-12-02T01:49:53ZDevelopment of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses1178-2013https://doaj.org/article/904be59b28824dbb8a258504bab4203e2014-08-01T00:00:00Zhttp://www.dovepress.com/development-of-nanofluorapatite-polymer-based-composite-for-bioactive--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Gangfeng Hu,1,2 Hui Wang,1 Xiaocong Yao,1 Dawei Bi,1 Gang Zhu,1 Songchao Tang,2 Jie Wei,2 Lili Yang,3 Peijian Tong,4 Luwei Xiao4 1The First People’s Hospital of Xiaoshang, Hangzhou, People’s Republic of China; 2Key Laboratory of Ultra-fine Materials, Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China; 3Department of Orthopedic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai, People’s Republic of China; 4Zhejiang Traditional Chinese Medical University, Hangzhou, People’s Republic of China Abstract: Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive strength and elastic modulus), hydrophilicity, and antibacterial properties of n-FA/PA12 composite were obviously improved by adding n-FA into PA12 as compared with PA12. In addition, cell proliferation of MC3T3-E1 cells cultured on n-FA/PA12 composite was significantly higher than with PA12, and alkaline phosphatase activity of MC3T3-E1 cells on the n-FA/PA12 composite was expressed at obviously higher levels as compared with PA12. The results suggest that n-FA/PA12 composite could support cell proliferation and differentiation, showing good cytocompatibility. Histological evaluation indicates that n-FA/PA12 composite enhances the efficiency of new bone formation with the introduction of n-FA into PA12, and the quantity of the newly formed bone for n-FA/PA12 composite is significantly higher than with PA12. In conclusion, n-FA/PA12 composite exhibits good biocompatibility and osteogenesis, which might be used for various orthopedic prostheses and dental implants. Keywords: nanofluorapatite, bioactive composites, cell behavior, orthopedic implantsHu GWang HYao XBi DZhu GTang SWei JYang LTong PXiao LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3875-3884 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hu G Wang H Yao X Bi D Zhu G Tang S Wei J Yang L Tong P Xiao L Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
description	Gangfeng Hu,1,2 Hui Wang,1 Xiaocong Yao,1 Dawei Bi,1 Gang Zhu,1 Songchao Tang,2 Jie Wei,2 Lili Yang,3 Peijian Tong,4 Luwei Xiao4 1The First People’s Hospital of Xiaoshang, Hangzhou, People’s Republic of China; 2Key Laboratory of Ultra-fine Materials, Ministry of Education, East China University of Science and Technology, Shanghai, People’s Republic of China; 3Department of Orthopedic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai, People’s Republic of China; 4Zhejiang Traditional Chinese Medical University, Hangzhou, People’s Republic of China Abstract: Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive strength and elastic modulus), hydrophilicity, and antibacterial properties of n-FA/PA12 composite were obviously improved by adding n-FA into PA12 as compared with PA12. In addition, cell proliferation of MC3T3-E1 cells cultured on n-FA/PA12 composite was significantly higher than with PA12, and alkaline phosphatase activity of MC3T3-E1 cells on the n-FA/PA12 composite was expressed at obviously higher levels as compared with PA12. The results suggest that n-FA/PA12 composite could support cell proliferation and differentiation, showing good cytocompatibility. Histological evaluation indicates that n-FA/PA12 composite enhances the efficiency of new bone formation with the introduction of n-FA into PA12, and the quantity of the newly formed bone for n-FA/PA12 composite is significantly higher than with PA12. In conclusion, n-FA/PA12 composite exhibits good biocompatibility and osteogenesis, which might be used for various orthopedic prostheses and dental implants. Keywords: nanofluorapatite, bioactive composites, cell behavior, orthopedic implants
format	article
author	Hu G Wang H Yao X Bi D Zhu G Tang S Wei J Yang L Tong P Xiao L
author_facet	Hu G Wang H Yao X Bi D Zhu G Tang S Wei J Yang L Tong P Xiao L
author_sort	Hu G
title	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_short	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_full	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_fullStr	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_full_unstemmed	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_sort	development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/904be59b28824dbb8a258504bab4203e
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_version_	1718402854974128128

Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses

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