SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE

Abstract. Besides the multiple hydrolytic enzymes, lysosomes are equipped with proteins apt to activate sphyngo-lipids — saposins (SAP). SAP belong to a broad and diverse family of moderate-size (~80 AA) saposin-like proteins (SAPLIP) containing specific domains with three disulfid e bonds bridging...

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Autores principales:	V. V. Yeremeev, A. S. Apt
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	saposins saposin-like proteins immunity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/904c3c32ac15408f98979553e39e666b
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spelling	oai:doaj.org-article:904c3c32ac15408f98979553e39e666b2021-11-22T07:09:45ZSAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE2220-76192313-739810.15789/2220-7619-2012-3-597-602https://doaj.org/article/904c3c32ac15408f98979553e39e666b2014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/75https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Besides the multiple hydrolytic enzymes, lysosomes are equipped with proteins apt to activate sphyngo-lipids — saposins (SAP). SAP belong to a broad and diverse family of moderate-size (~80 AA) saposin-like proteins (SAPLIP) containing specific domains with three disulfid e bonds bridging six cysteine residues. The diversity of SAPLIPS is likely explained by their involvement in distinct phases of engulfed bacteria digesting. Functionally similar SAPLIP were identified in a wide range of species — from amoeba to mammals, including humans. Saposins per se form a subfamily with six members: saposins A-D and the protein GM2 which possesses activatory functions. SAP do not have enzymatic activity, are heat-stable and protease resistant. The major in vivo function of SAP is released via participation in sphyngolipid catabolism and membrane digestion. In addition, complex association of SAP with membrane bi-layer and CD1 glycolipids is essential for loading lipid antigens onto antigen-presenting CD1 molecules for subsequent activation of lipid-specific T-cells. Of particular interest is participation of SAP in cross-presentation of bacterial antigens to CD8+ T-cells. A broad spectrum of SAP and SAPLIP involvement in the reactions of innate and adaptive immunity indicates their evolutionary conserved role in host defense.V. V. YeremeevA. S. AptSankt-Peterburg : NIIÈM imeni Pasteraarticlesaposinssaposin-like proteinsimmunityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 3, Pp 597-602 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	saposins saposin-like proteins immunity Infectious and parasitic diseases RC109-216
spellingShingle	saposins saposin-like proteins immunity Infectious and parasitic diseases RC109-216 V. V. Yeremeev A. S. Apt SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE
description	Abstract. Besides the multiple hydrolytic enzymes, lysosomes are equipped with proteins apt to activate sphyngo-lipids — saposins (SAP). SAP belong to a broad and diverse family of moderate-size (~80 AA) saposin-like proteins (SAPLIP) containing specific domains with three disulfid e bonds bridging six cysteine residues. The diversity of SAPLIPS is likely explained by their involvement in distinct phases of engulfed bacteria digesting. Functionally similar SAPLIP were identified in a wide range of species — from amoeba to mammals, including humans. Saposins per se form a subfamily with six members: saposins A-D and the protein GM2 which possesses activatory functions. SAP do not have enzymatic activity, are heat-stable and protease resistant. The major in vivo function of SAP is released via participation in sphyngolipid catabolism and membrane digestion. In addition, complex association of SAP with membrane bi-layer and CD1 glycolipids is essential for loading lipid antigens onto antigen-presenting CD1 molecules for subsequent activation of lipid-specific T-cells. Of particular interest is participation of SAP in cross-presentation of bacterial antigens to CD8+ T-cells. A broad spectrum of SAP and SAPLIP involvement in the reactions of innate and adaptive immunity indicates their evolutionary conserved role in host defense.
format	article
author	V. V. Yeremeev A. S. Apt
author_facet	V. V. Yeremeev A. S. Apt
author_sort	V. V. Yeremeev
title	SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE
title_short	SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE
title_full	SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE
title_fullStr	SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE
title_full_unstemmed	SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE
title_sort	saposin-like proteins in anti-infectious immune response
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/904c3c32ac15408f98979553e39e666b
work_keys_str_mv	AT vvyeremeev saposinlikeproteinsinantiinfectiousimmuneresponse AT asapt saposinlikeproteinsinantiinfectiousimmuneresponse
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SAPOSIN-LIKE PROTEINS IN ANTI-INFECTIOUS IMMUNE RESPONSE

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