Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies

The environment and personnel are both exposed to powdered pharmaceuticals inside pharmacies. This makes developing new methods for rapidly determining such contaminants an important objective. In this study, we developed a liquid-chromatography tandem-mass-spectrometry (LC–MS/MS) method for the sim...

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Autores principales:	Shiori Hasegawa BPharm, Ryoichi Inaba MD, PhD, Hiroki Nakamura RPh, Yamato Kato BPharm, Satoshi Nakao BPharm, Kouseki Hirade RPh, PhD, Takaaki Suzuki RPh, Mari Iwata RPh, Takeshi Kato RPh, Kazuhiro Iguchi RPh, PhD, Masahide Yamada RPh, Atsushi Hioki MD, PhD, Mitsuhiro Nakamura RPh, PhD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/904fac3d961e41369fae5dc843d30e7d
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spelling	oai:doaj.org-article:904fac3d961e41369fae5dc843d30e7d2021-12-01T22:35:38ZDevelopment of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies0046-95801945-724310.1177/00469580211059281https://doaj.org/article/904fac3d961e41369fae5dc843d30e7d2021-11-01T00:00:00Zhttps://doi.org/10.1177/00469580211059281https://doaj.org/toc/0046-9580https://doaj.org/toc/1945-7243The environment and personnel are both exposed to powdered pharmaceuticals inside pharmacies. This makes developing new methods for rapidly determining such contaminants an important objective. In this study, we developed a liquid-chromatography tandem-mass-spectrometry (LC–MS/MS) method for the simultaneous qualitative and quantitative determination of powdered medicinal drugs, such as famotidine, risperidone, lansoprazole, olanzapine, haloperidol, clarithromycin, promethazine, levomepromazine, and chlorpromazine. The method involves the use of acetaminophen as the internal standard, an LC–MS/MS method with a core–shell column, and a 10 mM ammonium formate/acetonitrile gradient mobile phase. The analytes were separated within 14 min, and MS with an electrospray ionization source in positive-ion mode was used. The limits of detection for the 9 drugs were .1-8.4 ng/mL. Linear calibration curves in the 10-50 000 ng/mL range were constructed, and inter-day accuracies of 92.6-113.8% were determined for the 9 drugs. The coefficients of variation were less than 14.6%. These data suggest that the proposed method is applicable for the routine assaying of powdered-medicine contamination in pharmacies.Shiori Hasegawa BPharmRyoichi Inaba MD, PhDHiroki Nakamura RPhYamato Kato BPharmSatoshi Nakao BPharmKouseki Hirade RPh, PhDTakaaki Suzuki RPhMari Iwata RPhTakeshi Kato RPhKazuhiro Iguchi RPh, PhDMasahide Yamada RPhAtsushi Hioki MD, PhDMitsuhiro Nakamura RPh, PhDSAGE PublishingarticlePublic aspects of medicineRA1-1270ENInquiry: The Journal of Health Care Organization, Provision, and Financing, Vol 58 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Public aspects of medicine RA1-1270
spellingShingle	Public aspects of medicine RA1-1270 Shiori Hasegawa BPharm Ryoichi Inaba MD, PhD Hiroki Nakamura RPh Yamato Kato BPharm Satoshi Nakao BPharm Kouseki Hirade RPh, PhD Takaaki Suzuki RPh Mari Iwata RPh Takeshi Kato RPh Kazuhiro Iguchi RPh, PhD Masahide Yamada RPh Atsushi Hioki MD, PhD Mitsuhiro Nakamura RPh, PhD Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
description	The environment and personnel are both exposed to powdered pharmaceuticals inside pharmacies. This makes developing new methods for rapidly determining such contaminants an important objective. In this study, we developed a liquid-chromatography tandem-mass-spectrometry (LC–MS/MS) method for the simultaneous qualitative and quantitative determination of powdered medicinal drugs, such as famotidine, risperidone, lansoprazole, olanzapine, haloperidol, clarithromycin, promethazine, levomepromazine, and chlorpromazine. The method involves the use of acetaminophen as the internal standard, an LC–MS/MS method with a core–shell column, and a 10 mM ammonium formate/acetonitrile gradient mobile phase. The analytes were separated within 14 min, and MS with an electrospray ionization source in positive-ion mode was used. The limits of detection for the 9 drugs were .1-8.4 ng/mL. Linear calibration curves in the 10-50 000 ng/mL range were constructed, and inter-day accuracies of 92.6-113.8% were determined for the 9 drugs. The coefficients of variation were less than 14.6%. These data suggest that the proposed method is applicable for the routine assaying of powdered-medicine contamination in pharmacies.
format	article
author	Shiori Hasegawa BPharm Ryoichi Inaba MD, PhD Hiroki Nakamura RPh Yamato Kato BPharm Satoshi Nakao BPharm Kouseki Hirade RPh, PhD Takaaki Suzuki RPh Mari Iwata RPh Takeshi Kato RPh Kazuhiro Iguchi RPh, PhD Masahide Yamada RPh Atsushi Hioki MD, PhD Mitsuhiro Nakamura RPh, PhD
author_facet	Shiori Hasegawa BPharm Ryoichi Inaba MD, PhD Hiroki Nakamura RPh Yamato Kato BPharm Satoshi Nakao BPharm Kouseki Hirade RPh, PhD Takaaki Suzuki RPh Mari Iwata RPh Takeshi Kato RPh Kazuhiro Iguchi RPh, PhD Masahide Yamada RPh Atsushi Hioki MD, PhD Mitsuhiro Nakamura RPh, PhD
author_sort	Shiori Hasegawa BPharm
title	Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
title_short	Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
title_full	Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
title_fullStr	Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
title_full_unstemmed	Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies
title_sort	development of liquid-chromatography tandem-mass-spectrometry method for determining environmental contamination by powdered medicinal drugs in pharmacies
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/904fac3d961e41369fae5dc843d30e7d
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Development of Liquid-Chromatography Tandem-Mass-Spectrometry Method for Determining Environmental Contamination by Powdered Medicinal Drugs in Pharmacies

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