Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia

Objectives: This study aims to assess the feasibility of using hemofiltration for ammonia clearance in low body weight infants with an inborn error of metabolism.Design: A study of two cases.Setting: Quaternary pediatric hospital (Saint Louis Children's Hospital) NICU and PICU.Patients: Infants...

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Autores principales:	Christopher Markham, Caroline Williams, Cory Miller, Dorothy K. Grange, T. Keefe Davis, Kenneth E. Remy
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hyperammonemia hemodialysis neonate citrullinemia methylmalonic acidemia Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/904fba66269045f9aac61dbca31f0684
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spelling	oai:doaj.org-article:904fba66269045f9aac61dbca31f06842021-11-05T14:50:53ZContinuous Renal Replacement Therapy for Two Neonates With Hyperammonemia2296-236010.3389/fped.2021.732354https://doaj.org/article/904fba66269045f9aac61dbca31f06842021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.732354/fullhttps://doaj.org/toc/2296-2360Objectives: This study aims to assess the feasibility of using hemofiltration for ammonia clearance in low body weight infants with an inborn error of metabolism.Design: A study of two cases.Setting: Quaternary pediatric hospital (Saint Louis Children's Hospital) NICU and PICU.Patients: Infants <6 months of age with an ICD-9 diagnosis of 270.6 (hyperammonemia).Interventions: Continuous renal replacement therapy (CRRT).Measurements and Main Results: We measure serum ammonia levels over time and the rate of ammonia clearance over time. Continuous renal replacement therapy was more effective than scavenger therapy alone (Ammonul™) for rapid removal of ammonia in low weight infants (as low as 2.5 kg).Conclusions: Continuous renal replacement therapy is technically feasible in low weight infants with severe hyperammonemia secondary to an inborn error of metabolism.Christopher MarkhamCaroline WilliamsCory MillerDorothy K. GrangeT. Keefe DavisKenneth E. RemyKenneth E. RemyFrontiers Media S.A.articlehyperammonemiahemodialysisneonatecitrullinemiamethylmalonic acidemiaPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperammonemia hemodialysis neonate citrullinemia methylmalonic acidemia Pediatrics RJ1-570
spellingShingle	hyperammonemia hemodialysis neonate citrullinemia methylmalonic acidemia Pediatrics RJ1-570 Christopher Markham Caroline Williams Cory Miller Dorothy K. Grange T. Keefe Davis Kenneth E. Remy Kenneth E. Remy Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
description	Objectives: This study aims to assess the feasibility of using hemofiltration for ammonia clearance in low body weight infants with an inborn error of metabolism.Design: A study of two cases.Setting: Quaternary pediatric hospital (Saint Louis Children's Hospital) NICU and PICU.Patients: Infants <6 months of age with an ICD-9 diagnosis of 270.6 (hyperammonemia).Interventions: Continuous renal replacement therapy (CRRT).Measurements and Main Results: We measure serum ammonia levels over time and the rate of ammonia clearance over time. Continuous renal replacement therapy was more effective than scavenger therapy alone (Ammonul™) for rapid removal of ammonia in low weight infants (as low as 2.5 kg).Conclusions: Continuous renal replacement therapy is technically feasible in low weight infants with severe hyperammonemia secondary to an inborn error of metabolism.
format	article
author	Christopher Markham Caroline Williams Cory Miller Dorothy K. Grange T. Keefe Davis Kenneth E. Remy Kenneth E. Remy
author_facet	Christopher Markham Caroline Williams Cory Miller Dorothy K. Grange T. Keefe Davis Kenneth E. Remy Kenneth E. Remy
author_sort	Christopher Markham
title	Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
title_short	Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
title_full	Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
title_fullStr	Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
title_full_unstemmed	Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
title_sort	continuous renal replacement therapy for two neonates with hyperammonemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/904fba66269045f9aac61dbca31f0684
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Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia

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