Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.

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Autores principales:	Ning Liang, Anastasius Damdimopoulos, Saioa Goñi, Zhiqiang Huang, Lise-Lotte Vedin, Tomas Jakobsson, Marco Giudici, Osman Ahmed, Matteo Pedrelli, Serena Barilla, Fawaz Alzaid, Arturo Mendoza, Tarja Schröder, Raoul Kuiper, Paolo Parini, Anthony Hollenberg, Philippe Lefebvre, Sven Francque, Luc Van Gaal, Bart Staels, Nicolas Venteclef, Eckardt Treuter, Rongrong Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90508a91d07f4ebf99f099ffd68ebc8f
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spelling	oai:doaj.org-article:90508a91d07f4ebf99f099ffd68ebc8f2021-12-02T16:57:50ZHepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα10.1038/s41467-019-09524-z2041-1723https://doaj.org/article/90508a91d07f4ebf99f099ffd68ebc8f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09524-zhttps://doaj.org/toc/2041-1723Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.Ning LiangAnastasius DamdimopoulosSaioa GoñiZhiqiang HuangLise-Lotte VedinTomas JakobssonMarco GiudiciOsman AhmedMatteo PedrelliSerena BarillaFawaz AlzaidArturo MendozaTarja SchröderRaoul KuiperPaolo PariniAnthony HollenbergPhilippe LefebvreSven FrancqueLuc Van GaalBart StaelsNicolas VenteclefEckardt TreuterRongrong FanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ning Liang Anastasius Damdimopoulos Saioa Goñi Zhiqiang Huang Lise-Lotte Vedin Tomas Jakobsson Marco Giudici Osman Ahmed Matteo Pedrelli Serena Barilla Fawaz Alzaid Arturo Mendoza Tarja Schröder Raoul Kuiper Paolo Parini Anthony Hollenberg Philippe Lefebvre Sven Francque Luc Van Gaal Bart Staels Nicolas Venteclef Eckardt Treuter Rongrong Fan Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
description	Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.
format	article
author	Ning Liang Anastasius Damdimopoulos Saioa Goñi Zhiqiang Huang Lise-Lotte Vedin Tomas Jakobsson Marco Giudici Osman Ahmed Matteo Pedrelli Serena Barilla Fawaz Alzaid Arturo Mendoza Tarja Schröder Raoul Kuiper Paolo Parini Anthony Hollenberg Philippe Lefebvre Sven Francque Luc Van Gaal Bart Staels Nicolas Venteclef Eckardt Treuter Rongrong Fan
author_facet	Ning Liang Anastasius Damdimopoulos Saioa Goñi Zhiqiang Huang Lise-Lotte Vedin Tomas Jakobsson Marco Giudici Osman Ahmed Matteo Pedrelli Serena Barilla Fawaz Alzaid Arturo Mendoza Tarja Schröder Raoul Kuiper Paolo Parini Anthony Hollenberg Philippe Lefebvre Sven Francque Luc Van Gaal Bart Staels Nicolas Venteclef Eckardt Treuter Rongrong Fan
author_sort	Ning Liang
title	Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
title_short	Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
title_full	Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
title_fullStr	Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
title_full_unstemmed	Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
title_sort	hepatocyte-specific loss of gps2 in mice reduces non-alcoholic steatohepatitis via activation of pparα
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/90508a91d07f4ebf99f099ffd68ebc8f
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Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

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