Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma

Pyroptosis is a novel kind of cellular necrosis and shown to be involved in cancer progression. However, the diverse expression, prognosis and associations with immune status of pyroptosis-related genes in Hepatocellular carcinoma (HCC) have yet to be analyzed. Herein, the expression profiles and co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Susu Zheng, Xiaoying Xie, Xinkun Guo, Yanfang Wu, Guobin Chen, Xiaochun Chen, Meixia Wang, Tongchun Xue, Boheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pyroptosis hepatocellular carcinoma prognosis immune infiltrates immune checkpoint inhibitors Genetics QH426-470
Acceso en línea:	https://doaj.org/article/9050a44324834b1da796f3c6709826d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9050a44324834b1da796f3c6709826d0
record_format	dspace
spelling	oai:doaj.org-article:9050a44324834b1da796f3c6709826d02021-12-03T06:53:54ZIdentification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma1664-802110.3389/fgene.2021.789296https://doaj.org/article/9050a44324834b1da796f3c6709826d02021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.789296/fullhttps://doaj.org/toc/1664-8021Pyroptosis is a novel kind of cellular necrosis and shown to be involved in cancer progression. However, the diverse expression, prognosis and associations with immune status of pyroptosis-related genes in Hepatocellular carcinoma (HCC) have yet to be analyzed. Herein, the expression profiles and corresponding clinical characteristics of HCC samples were collected from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Then a pyroptosis-related gene signature was built by applying the least absolute shrinkage and selection operator (LASSO) Cox regression model from the TCGA cohort, while the GEO datasets were applied for verification. Twenty-four pyroptosis-related genes were found to be differentially expressed between HCC and normal samples. A five pyroptosis-related gene signature (GSDME, CASP8, SCAF11, NOD2, CASP6) was constructed according to LASSO Cox regression model. Patients in the low-risk group had better survival rates than those in the high-risk group. The risk score was proved to be an independent prognostic factor for overall survival (OS). The risk score correlated with immune infiltrations and immunotherapy responses. GSEA indicated that endocytosis, ubiquitin mediated proteolysis and regulation of autophagy were enriched in the high-risk group, while drug metabolism cytochrome P450 and tryptophan metabolism were enriched in the low-risk group. In conclusion, our pyroptosis-related gene signature can be used for survival prediction and may also predict the response of immunotherapy.Susu ZhengSusu ZhengXiaoying XieXiaoying XieXinkun GuoYanfang WuGuobin ChenXiaochun ChenMeixia WangTongchun XueBoheng ZhangBoheng ZhangBoheng ZhangFrontiers Media S.A.articlepyroptosishepatocellular carcinomaprognosisimmune infiltratesimmune checkpoint inhibitorsGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyroptosis hepatocellular carcinoma prognosis immune infiltrates immune checkpoint inhibitors Genetics QH426-470
spellingShingle	pyroptosis hepatocellular carcinoma prognosis immune infiltrates immune checkpoint inhibitors Genetics QH426-470 Susu Zheng Susu Zheng Xiaoying Xie Xiaoying Xie Xinkun Guo Yanfang Wu Guobin Chen Xiaochun Chen Meixia Wang Tongchun Xue Boheng Zhang Boheng Zhang Boheng Zhang Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
description	Pyroptosis is a novel kind of cellular necrosis and shown to be involved in cancer progression. However, the diverse expression, prognosis and associations with immune status of pyroptosis-related genes in Hepatocellular carcinoma (HCC) have yet to be analyzed. Herein, the expression profiles and corresponding clinical characteristics of HCC samples were collected from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Then a pyroptosis-related gene signature was built by applying the least absolute shrinkage and selection operator (LASSO) Cox regression model from the TCGA cohort, while the GEO datasets were applied for verification. Twenty-four pyroptosis-related genes were found to be differentially expressed between HCC and normal samples. A five pyroptosis-related gene signature (GSDME, CASP8, SCAF11, NOD2, CASP6) was constructed according to LASSO Cox regression model. Patients in the low-risk group had better survival rates than those in the high-risk group. The risk score was proved to be an independent prognostic factor for overall survival (OS). The risk score correlated with immune infiltrations and immunotherapy responses. GSEA indicated that endocytosis, ubiquitin mediated proteolysis and regulation of autophagy were enriched in the high-risk group, while drug metabolism cytochrome P450 and tryptophan metabolism were enriched in the low-risk group. In conclusion, our pyroptosis-related gene signature can be used for survival prediction and may also predict the response of immunotherapy.
format	article
author	Susu Zheng Susu Zheng Xiaoying Xie Xiaoying Xie Xinkun Guo Yanfang Wu Guobin Chen Xiaochun Chen Meixia Wang Tongchun Xue Boheng Zhang Boheng Zhang Boheng Zhang
author_facet	Susu Zheng Susu Zheng Xiaoying Xie Xiaoying Xie Xinkun Guo Yanfang Wu Guobin Chen Xiaochun Chen Meixia Wang Tongchun Xue Boheng Zhang Boheng Zhang Boheng Zhang
author_sort	Susu Zheng
title	Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
title_short	Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
title_full	Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
title_fullStr	Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
title_full_unstemmed	Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma
title_sort	identification of a pyroptosis-related gene signature for predicting overall survival and response to immunotherapy in hepatocellular carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9050a44324834b1da796f3c6709826d0
work_keys_str_mv	AT susuzheng identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT susuzheng identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT xiaoyingxie identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT xiaoyingxie identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT xinkunguo identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT yanfangwu identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT guobinchen identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT xiaochunchen identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT meixiawang identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT tongchunxue identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT bohengzhang identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT bohengzhang identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma AT bohengzhang identificationofapyroptosisrelatedgenesignatureforpredictingoverallsurvivalandresponsetoimmunotherapyinhepatocellularcarcinoma
_version_	1718373885060055040

Identification of a Pyroptosis-Related Gene Signature for Predicting Overall Survival and Response to Immunotherapy in Hepatocellular Carcinoma

Ejemplares similares