Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer

Abstract The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and i...

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Autores principales:	Akira Yoshida, Tomoaki Takata, Tsutomu Kanda, Naoyuki Yamaguchi, Hitomi Minami, Kazuhiko Nakao, Shinichiro Kobayashi, Susumu Eguchi, Hajime Isomoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90523de97ceb4b6f9d7f53f57d047257
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spelling	oai:doaj.org-article:90523de97ceb4b6f9d7f53f57d0472572021-12-02T16:31:52ZImpact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer10.1038/s41598-021-94871-52045-2322https://doaj.org/article/90523de97ceb4b6f9d7f53f57d0472572021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94871-5https://doaj.org/toc/2045-2322Abstract The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. However, the cytokine crosstalk involved in the oesophageal cancer TME and post-ESD stricture has not been fully elucidated. This study investigated the comprehensive cytokine dynamics following ESD in patients with oesophageal cancer. In addition, the effect of a novel preventive technique for post-ESD stricture, autologous cell sheet engraftment, on cytokine levels was evaluated. Various pro-inflammatory and anti-tumorigenic cytokines were elevated in patients with oesophageal cancer, and ESD transiently influenced cytokine concentrations. IL-1β and TNF-α, two major pro-inflammatory cytokines that induce oesophageal stricture, were significantly suppressed by cell sheet engraftment. In conclusion, this study revealed the distinct cytokine dynamics after ESD in patients with oesophageal cancer, together with the effect of autologous cell sheet engraftment on cytokine fluctuation. These results can accelerate research on the TME and therapeutic strategies for oesophageal cancer.Akira YoshidaTomoaki TakataTsutomu KandaNaoyuki YamaguchiHitomi MinamiKazuhiko NakaoShinichiro KobayashiSusumu EguchiHajime IsomotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akira Yoshida Tomoaki Takata Tsutomu Kanda Naoyuki Yamaguchi Hitomi Minami Kazuhiko Nakao Shinichiro Kobayashi Susumu Eguchi Hajime Isomoto Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
description	Abstract The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. However, the cytokine crosstalk involved in the oesophageal cancer TME and post-ESD stricture has not been fully elucidated. This study investigated the comprehensive cytokine dynamics following ESD in patients with oesophageal cancer. In addition, the effect of a novel preventive technique for post-ESD stricture, autologous cell sheet engraftment, on cytokine levels was evaluated. Various pro-inflammatory and anti-tumorigenic cytokines were elevated in patients with oesophageal cancer, and ESD transiently influenced cytokine concentrations. IL-1β and TNF-α, two major pro-inflammatory cytokines that induce oesophageal stricture, were significantly suppressed by cell sheet engraftment. In conclusion, this study revealed the distinct cytokine dynamics after ESD in patients with oesophageal cancer, together with the effect of autologous cell sheet engraftment on cytokine fluctuation. These results can accelerate research on the TME and therapeutic strategies for oesophageal cancer.
format	article
author	Akira Yoshida Tomoaki Takata Tsutomu Kanda Naoyuki Yamaguchi Hitomi Minami Kazuhiko Nakao Shinichiro Kobayashi Susumu Eguchi Hajime Isomoto
author_facet	Akira Yoshida Tomoaki Takata Tsutomu Kanda Naoyuki Yamaguchi Hitomi Minami Kazuhiko Nakao Shinichiro Kobayashi Susumu Eguchi Hajime Isomoto
author_sort	Akira Yoshida
title	Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_short	Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_full	Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_fullStr	Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_full_unstemmed	Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
title_sort	impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90523de97ceb4b6f9d7f53f57d047257
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Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer

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