Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study

Abstract The American Joint Committee on Cancer (AJCC) 8th TNM staging system of differentiated thyroid cancer defines gross strap muscle invasion as T3b stage. However, the impact of strap muscle invasion on disease-specific survival (DSS) remains controversial. To elucidate the survival impact of...

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Autores principales:	Ja Kyung Yoon, Jandee Lee, Eun-Kyung Kim, Jung Hyun Yoon, Vivian Youngjean Park, Kyunghwa Han, Jin Young Kwak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/905386157b77432888f2d240af077ce7
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spelling	oai:doaj.org-article:905386157b77432888f2d240af077ce72021-12-02T15:10:05ZStrap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study10.1038/s41598-020-75161-y2045-2322https://doaj.org/article/905386157b77432888f2d240af077ce72020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-75161-yhttps://doaj.org/toc/2045-2322Abstract The American Joint Committee on Cancer (AJCC) 8th TNM staging system of differentiated thyroid cancer defines gross strap muscle invasion as T3b stage. However, the impact of strap muscle invasion on disease-specific survival (DSS) remains controversial. To elucidate the survival impact of strap muscle invasion of any degree in thyroid cancers, the Surveillance, Epidemiology, and End Results (SEER) database (1973–2018) was queried for thyroid cancer only patients on July 2019 (n = 19,914). The Cox proportional hazard analysis with multivariable adjustment revealed that strap muscle invasion was not a significant factor for DSS in tumors equal to or smaller than 40 mm (hazard ratio (HR) = 1.620 [confidence interval (CI) 0.917 – 2.860]; p = 0.097). The competing risk analysis with multivariable adjustment showed that strap muscle invasion did not significantly impact DSS regardless of tumor size or cause of death (cancer-caused death (Subdistribution HR (SDHR) = 1.567 [CI 0.984 – 2.495]; p = 0.059); deaths to other causes (SDHR = 1.155 [CI 0.842 – 1.585]; p = 0.370). A “modified” staging schema discarding strap muscle invasion as a T stage criterion showed better 10-year DSS distinction between T stages. The modified staging schema may better reflect cancer-caused death risk and may prevent potential overstaging.Ja Kyung YoonJandee LeeEun-Kyung KimJung Hyun YoonVivian Youngjean ParkKyunghwa HanJin Young KwakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ja Kyung Yoon Jandee Lee Eun-Kyung Kim Jung Hyun Yoon Vivian Youngjean Park Kyunghwa Han Jin Young Kwak Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
description	Abstract The American Joint Committee on Cancer (AJCC) 8th TNM staging system of differentiated thyroid cancer defines gross strap muscle invasion as T3b stage. However, the impact of strap muscle invasion on disease-specific survival (DSS) remains controversial. To elucidate the survival impact of strap muscle invasion of any degree in thyroid cancers, the Surveillance, Epidemiology, and End Results (SEER) database (1973–2018) was queried for thyroid cancer only patients on July 2019 (n = 19,914). The Cox proportional hazard analysis with multivariable adjustment revealed that strap muscle invasion was not a significant factor for DSS in tumors equal to or smaller than 40 mm (hazard ratio (HR) = 1.620 [confidence interval (CI) 0.917 – 2.860]; p = 0.097). The competing risk analysis with multivariable adjustment showed that strap muscle invasion did not significantly impact DSS regardless of tumor size or cause of death (cancer-caused death (Subdistribution HR (SDHR) = 1.567 [CI 0.984 – 2.495]; p = 0.059); deaths to other causes (SDHR = 1.155 [CI 0.842 – 1.585]; p = 0.370). A “modified” staging schema discarding strap muscle invasion as a T stage criterion showed better 10-year DSS distinction between T stages. The modified staging schema may better reflect cancer-caused death risk and may prevent potential overstaging.
format	article
author	Ja Kyung Yoon Jandee Lee Eun-Kyung Kim Jung Hyun Yoon Vivian Youngjean Park Kyunghwa Han Jin Young Kwak
author_facet	Ja Kyung Yoon Jandee Lee Eun-Kyung Kim Jung Hyun Yoon Vivian Youngjean Park Kyunghwa Han Jin Young Kwak
author_sort	Ja Kyung Yoon
title	Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
title_short	Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
title_full	Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
title_fullStr	Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
title_full_unstemmed	Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
title_sort	strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/905386157b77432888f2d240af077ce7
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Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study

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