Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study

Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is frequently an incidental finding during X-ray examination. Although it has been shown to be associated with several chronic diseases, the hazard of cerebrovascular disease has seldom been explored. Our study aimed at determining the risk of...

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Autores principales:	Yuan-Yang Cheng, Ching-Heng Lin, Po-Yi Tsai, Yi-Huei Chen, Shih-Yi Lin, Shin-Tsu Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/905a9b4b4d0547f1a55d6edd45eee930
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spelling	oai:doaj.org-article:905a9b4b4d0547f1a55d6edd45eee9302021-11-08T10:51:29ZIncreased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study10.1038/s41598-021-00798-22045-2322https://doaj.org/article/905a9b4b4d0547f1a55d6edd45eee9302021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00798-2https://doaj.org/toc/2045-2322Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is frequently an incidental finding during X-ray examination. Although it has been shown to be associated with several chronic diseases, the hazard of cerebrovascular disease has seldom been explored. Our study aimed at determining the risk of stroke conferred by DISH, which is a retrospective cohort study adopting the largest medical database in Taiwan. Patients with a diagnosis of DISH at least three times from 2005 to 2010 were identified as the study group, and those in the control group were selected by matching age and gender. Patients were followed up until the end of 2015 to trace the incidence of stroke. Cox regression analysis was performed to compute the hazard ratio of stroke. Among the included 5300 patients, 1060 had a diagnosis of DISH. Significantly higher prevalence rates of stroke, hypertension, diabetes, and hyperlipidemia were noted in these patients. Overall, DISH conferred a 1.68 times higher risk of developing stroke. The significantly higher hazard ratio could be identified in both genders whether hypertension existed or not. Even in those without comorbidities, DISH still conferred a significantly higher risk of cerebrovascular disease in the future, which should never be ignored when encountered during clinical practice.Yuan-Yang ChengChing-Heng LinPo-Yi TsaiYi-Huei ChenShih-Yi LinShin-Tsu ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan-Yang Cheng Ching-Heng Lin Po-Yi Tsai Yi-Huei Chen Shih-Yi Lin Shin-Tsu Chang Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
description	Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is frequently an incidental finding during X-ray examination. Although it has been shown to be associated with several chronic diseases, the hazard of cerebrovascular disease has seldom been explored. Our study aimed at determining the risk of stroke conferred by DISH, which is a retrospective cohort study adopting the largest medical database in Taiwan. Patients with a diagnosis of DISH at least three times from 2005 to 2010 were identified as the study group, and those in the control group were selected by matching age and gender. Patients were followed up until the end of 2015 to trace the incidence of stroke. Cox regression analysis was performed to compute the hazard ratio of stroke. Among the included 5300 patients, 1060 had a diagnosis of DISH. Significantly higher prevalence rates of stroke, hypertension, diabetes, and hyperlipidemia were noted in these patients. Overall, DISH conferred a 1.68 times higher risk of developing stroke. The significantly higher hazard ratio could be identified in both genders whether hypertension existed or not. Even in those without comorbidities, DISH still conferred a significantly higher risk of cerebrovascular disease in the future, which should never be ignored when encountered during clinical practice.
format	article
author	Yuan-Yang Cheng Ching-Heng Lin Po-Yi Tsai Yi-Huei Chen Shih-Yi Lin Shin-Tsu Chang
author_facet	Yuan-Yang Cheng Ching-Heng Lin Po-Yi Tsai Yi-Huei Chen Shih-Yi Lin Shin-Tsu Chang
author_sort	Yuan-Yang Cheng
title	Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
title_short	Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
title_full	Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
title_fullStr	Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
title_full_unstemmed	Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
title_sort	increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/905a9b4b4d0547f1a55d6edd45eee930
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Increased risk of stroke in patients with diffuse idiopathic skeletal hyperostosis: a nationwide population-based cohort study

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