A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice
BRCA1 is a key regulator of DNA double-strand break repair, functioning to promote homologous recombination and repress non-homologous end-joining. Here the authors show that the ubiquitin ligase UHRF1 is recruited to breaks by BRCA1, where it targets RIF1 and thereby facilitates recombination.
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Nature Portfolio
2016
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oai:doaj.org-article:905ad9b75a784c3680591b2baed06c352021-12-02T17:31:17ZA cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice10.1038/ncomms102012041-1723https://doaj.org/article/905ad9b75a784c3680591b2baed06c352016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10201https://doaj.org/toc/2041-1723BRCA1 is a key regulator of DNA double-strand break repair, functioning to promote homologous recombination and repress non-homologous end-joining. Here the authors show that the ubiquitin ligase UHRF1 is recruited to breaks by BRCA1, where it targets RIF1 and thereby facilitates recombination.Haoxing ZhangHailong LiuYali ChenXu YangPanfei WangTongzheng LiuMin DengBo QinCristina CorreiaSeungbaek LeeJungjin KimMelanie SparksAsha A. NairDebra L. EvansKrishna R. KalariPumin ZhangLiewei WangZhongsheng YouScott H. KaufmannZhenkun LouHuadong PeiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Haoxing Zhang Hailong Liu Yali Chen Xu Yang Panfei Wang Tongzheng Liu Min Deng Bo Qin Cristina Correia Seungbaek Lee Jungjin Kim Melanie Sparks Asha A. Nair Debra L. Evans Krishna R. Kalari Pumin Zhang Liewei Wang Zhongsheng You Scott H. Kaufmann Zhenkun Lou Huadong Pei A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice |
| description |
BRCA1 is a key regulator of DNA double-strand break repair, functioning to promote homologous recombination and repress non-homologous end-joining. Here the authors show that the ubiquitin ligase UHRF1 is recruited to breaks by BRCA1, where it targets RIF1 and thereby facilitates recombination. |
| format |
article |
| author |
Haoxing Zhang Hailong Liu Yali Chen Xu Yang Panfei Wang Tongzheng Liu Min Deng Bo Qin Cristina Correia Seungbaek Lee Jungjin Kim Melanie Sparks Asha A. Nair Debra L. Evans Krishna R. Kalari Pumin Zhang Liewei Wang Zhongsheng You Scott H. Kaufmann Zhenkun Lou Huadong Pei |
| author_facet |
Haoxing Zhang Hailong Liu Yali Chen Xu Yang Panfei Wang Tongzheng Liu Min Deng Bo Qin Cristina Correia Seungbaek Lee Jungjin Kim Melanie Sparks Asha A. Nair Debra L. Evans Krishna R. Kalari Pumin Zhang Liewei Wang Zhongsheng You Scott H. Kaufmann Zhenkun Lou Huadong Pei |
| author_sort |
Haoxing Zhang |
| title |
A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice |
| title_short |
A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice |
| title_full |
A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice |
| title_fullStr |
A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice |
| title_full_unstemmed |
A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice |
| title_sort |
cell cycle-dependent brca1–uhrf1 cascade regulates dna double-strand break repair pathway choice |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/905ad9b75a784c3680591b2baed06c35 |
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