The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more...

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Autores principales:	Conglei Li, Thergiory Irrazabal, Clare C. So, Maribel Berru, Likun Du, Evelyn Lam, Alexanda K. Ling, Jennifer L. Gommerman, Qiang Pan-Hammarström, Alberto Martin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/905ec0c6076f4a6599d3753a0f2a55ca
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spelling	oai:doaj.org-article:905ec0c6076f4a6599d3753a0f2a55ca2021-12-02T15:33:37ZThe H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining10.1038/s41467-018-03455-x2041-1723https://doaj.org/article/905ec0c6076f4a6599d3753a0f2a55ca2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03455-xhttps://doaj.org/toc/2041-1723Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more dependent on the alternative A-EJ pathway.Conglei LiThergiory IrrazabalClare C. SoMaribel BerruLikun DuEvelyn LamAlexanda K. LingJennifer L. GommermanQiang Pan-HammarströmAlberto MartinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Conglei Li Thergiory Irrazabal Clare C. So Maribel Berru Likun Du Evelyn Lam Alexanda K. Ling Jennifer L. Gommerman Qiang Pan-Hammarström Alberto Martin The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
description	Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more dependent on the alternative A-EJ pathway.
format	article
author	Conglei Li Thergiory Irrazabal Clare C. So Maribel Berru Likun Du Evelyn Lam Alexanda K. Ling Jennifer L. Gommerman Qiang Pan-Hammarström Alberto Martin
author_facet	Conglei Li Thergiory Irrazabal Clare C. So Maribel Berru Likun Du Evelyn Lam Alexanda K. Ling Jennifer L. Gommerman Qiang Pan-Hammarström Alberto Martin
author_sort	Conglei Li
title	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
title_short	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
title_full	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
title_fullStr	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
title_full_unstemmed	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
title_sort	h2b deubiquitinase usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/905ec0c6076f4a6599d3753a0f2a55ca
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The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

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