Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome

ABSTRACT Commonly prescribed antibiotics are known to alter human microbiota. We hypothesized that triclosan and triclocarban, components of many household and personal care products (HPCPs), may alter the oral and gut microbiota, with potential consequences for metabolic function and weight. In a d...

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Autores principales:	Angela C. Poole, Lauren Pischel, Catherine Ley, Gina Suh, Julia K. Goodrich, Thomas D. Haggerty, Ruth E. Ley, Julie Parsonnet
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	triclosan microbicide microbiome randomized double-blind crossover study Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/90618bdf529740c290eb1bade8de97f9
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spelling	oai:doaj.org-article:90618bdf529740c290eb1bade8de97f92021-11-15T15:21:18ZCrossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome10.1128/mSphere.00056-152379-5042https://doaj.org/article/90618bdf529740c290eb1bade8de97f92016-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00056-15https://doaj.org/toc/2379-5042ABSTRACT Commonly prescribed antibiotics are known to alter human microbiota. We hypothesized that triclosan and triclocarban, components of many household and personal care products (HPCPs), may alter the oral and gut microbiota, with potential consequences for metabolic function and weight. In a double-blind, randomized, crossover study, participants were given triclosan- and triclocarban (TCS)-containing or non-triclosan/triclocarban (nTCS)-containing HPCPs for 4 months and then switched to the other products for an additional 4 months. Blood, stool, gingival plaque, and urine samples and weight data were obtained at baseline and at regular intervals throughout the study period. Blood samples were analyzed for metabolic and endocrine markers and urine samples for triclosan. The microbiome in stool and oral samples was then analyzed. Although there was a significant difference in the amount of triclosan in the urine between the TCS and nTCS phases, no differences were found in microbiome composition, metabolic or endocrine markers, or weight. Though this study was limited by the small sample size and imprecise administration of HPCPs, triclosan at physiologic levels from exposure to HPCPs does not appear to have a significant or important impact on human oral or gut microbiome structure or on a panel of metabolic markers. IMPORTANCE Triclosan and triclocarban are commonly used commercial microbicides found in toothpastes and soaps. It is unknown what effects these chemicals have on the human microbiome or on endocrine function. From this randomized crossover study, it appears that routine personal care use of triclosan and triclocarban neither exerts a major influence on microbial communities in the gut and mouth nor alters markers of endocrine function in humans.Angela C. PooleLauren PischelCatherine LeyGina SuhJulia K. GoodrichThomas D. HaggertyRuth E. LeyJulie ParsonnetAmerican Society for Microbiologyarticletriclosanmicrobicidemicrobiomerandomized double-blind crossover studyMicrobiologyQR1-502ENmSphere, Vol 1, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	triclosan microbicide microbiome randomized double-blind crossover study Microbiology QR1-502
spellingShingle	triclosan microbicide microbiome randomized double-blind crossover study Microbiology QR1-502 Angela C. Poole Lauren Pischel Catherine Ley Gina Suh Julia K. Goodrich Thomas D. Haggerty Ruth E. Ley Julie Parsonnet Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome
description	ABSTRACT Commonly prescribed antibiotics are known to alter human microbiota. We hypothesized that triclosan and triclocarban, components of many household and personal care products (HPCPs), may alter the oral and gut microbiota, with potential consequences for metabolic function and weight. In a double-blind, randomized, crossover study, participants were given triclosan- and triclocarban (TCS)-containing or non-triclosan/triclocarban (nTCS)-containing HPCPs for 4 months and then switched to the other products for an additional 4 months. Blood, stool, gingival plaque, and urine samples and weight data were obtained at baseline and at regular intervals throughout the study period. Blood samples were analyzed for metabolic and endocrine markers and urine samples for triclosan. The microbiome in stool and oral samples was then analyzed. Although there was a significant difference in the amount of triclosan in the urine between the TCS and nTCS phases, no differences were found in microbiome composition, metabolic or endocrine markers, or weight. Though this study was limited by the small sample size and imprecise administration of HPCPs, triclosan at physiologic levels from exposure to HPCPs does not appear to have a significant or important impact on human oral or gut microbiome structure or on a panel of metabolic markers. IMPORTANCE Triclosan and triclocarban are commonly used commercial microbicides found in toothpastes and soaps. It is unknown what effects these chemicals have on the human microbiome or on endocrine function. From this randomized crossover study, it appears that routine personal care use of triclosan and triclocarban neither exerts a major influence on microbial communities in the gut and mouth nor alters markers of endocrine function in humans.
format	article
author	Angela C. Poole Lauren Pischel Catherine Ley Gina Suh Julia K. Goodrich Thomas D. Haggerty Ruth E. Ley Julie Parsonnet
author_facet	Angela C. Poole Lauren Pischel Catherine Ley Gina Suh Julia K. Goodrich Thomas D. Haggerty Ruth E. Ley Julie Parsonnet
author_sort	Angela C. Poole
title	Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome
title_short	Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome
title_full	Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome
title_fullStr	Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome
title_full_unstemmed	Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome
title_sort	crossover control study of the effect of personal care products containing triclosan on the microbiome
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/90618bdf529740c290eb1bade8de97f9
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Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome

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