The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.

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Detalles Bibliográficos
Autores principales: Ling Wang, Mary E. A. Howell, Ayrianna Sparks-Wallace, Juan Zhao, Culton R. Hensley, Camri A. Nicksic, Shanna R. Horne, Kaylea B. Mohr, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/9062215602b446458b173e626e8fb19d
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Sumario:As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.