A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics

Previous studies in population genetics have proposed that the Y-chromosomal (Y-DNA) haplogroup D ancestor likely originated from Africa. The haplogroup D branch next started Out-of-Africa migration, rapidly expanded across Eurasia, and later diversified in East Asia. Y-DNA haplogroup D-M55, one of...

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Autores principales:	Masahiro Matsunaga, Yohsuke Ohtsubo, Takahiko Masuda, Yasuki Noguchi, Hidenori Yamasue, Keiko Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	haplogroup D-M55 gene polymorphism (genetics) body mass index - BMI close friends gene–gene interaction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/906360b2cb6e4606b9d23c93538d6ee4
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spelling	oai:doaj.org-article:906360b2cb6e4606b9d23c93538d6ee42021-12-02T17:10:35ZA Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics1662-515310.3389/fnbeh.2021.774879https://doaj.org/article/906360b2cb6e4606b9d23c93538d6ee42021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.774879/fullhttps://doaj.org/toc/1662-5153Previous studies in population genetics have proposed that the Y-chromosomal (Y-DNA) haplogroup D ancestor likely originated from Africa. The haplogroup D branch next started Out-of-Africa migration, rapidly expanded across Eurasia, and later diversified in East Asia. Y-DNA haplogroup D-M55, one of the branches of haplogroup D, is only found in modern Japanese males, suggesting that individuals with Y-DNA haplogroup D migrated from the Eurasian continent. Based on previous observations, Y-DNA haplogroup D is expected to be associated with some male characteristics including personality. Therefore, this study investigated whether the Y-DNA haplogroup D-M55 is associated with several physiological and psychological characteristics, including exploratory motivation and human relationship-related perception. We recruited Japanese young adult males and females and investigated the association between Y-DNA haplogroup D-M55, physiological [body mass index (BMI)], and several psychological parameters [perceived number of close friends, behavioral inhibition system/behavioral activation system (BIS/BAS), perceived happiness, and perceived loneliness]. The results indicated that males with haplogroup D-M55 had a higher BMI and more close friends, compared with non-carrier males. Additional multiple regression analyses, which tested the hypothesis that haplogroup D-M55 predicts BMI and perceived number of close friends, confirmed our hypothesis, even after controlling for the potentially confounding variables of age and sex. We also analyzed the gene–gene interaction between haplogroup D-M55 and an autosomal gene polymorphism associated with BMI and human relationships, such as the dopamine D2 receptor gene (DRD2: rs1800497). Results showed gene–gene interactions between haplogroups D-M55 and DRD2 in BMI. Based on these findings, it is demonstrated that Y-DNA haplogroup D is associated with human personality.Masahiro MatsunagaYohsuke OhtsuboTakahiko MasudaYasuki NoguchiHidenori YamasueKeiko IshiiFrontiers Media S.A.articlehaplogroup D-M55gene polymorphism (genetics)body mass index - BMIclose friendsgene–gene interactionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	haplogroup D-M55 gene polymorphism (genetics) body mass index - BMI close friends gene–gene interaction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	haplogroup D-M55 gene polymorphism (genetics) body mass index - BMI close friends gene–gene interaction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Masahiro Matsunaga Yohsuke Ohtsubo Takahiko Masuda Yasuki Noguchi Hidenori Yamasue Keiko Ishii A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics
description	Previous studies in population genetics have proposed that the Y-chromosomal (Y-DNA) haplogroup D ancestor likely originated from Africa. The haplogroup D branch next started Out-of-Africa migration, rapidly expanded across Eurasia, and later diversified in East Asia. Y-DNA haplogroup D-M55, one of the branches of haplogroup D, is only found in modern Japanese males, suggesting that individuals with Y-DNA haplogroup D migrated from the Eurasian continent. Based on previous observations, Y-DNA haplogroup D is expected to be associated with some male characteristics including personality. Therefore, this study investigated whether the Y-DNA haplogroup D-M55 is associated with several physiological and psychological characteristics, including exploratory motivation and human relationship-related perception. We recruited Japanese young adult males and females and investigated the association between Y-DNA haplogroup D-M55, physiological [body mass index (BMI)], and several psychological parameters [perceived number of close friends, behavioral inhibition system/behavioral activation system (BIS/BAS), perceived happiness, and perceived loneliness]. The results indicated that males with haplogroup D-M55 had a higher BMI and more close friends, compared with non-carrier males. Additional multiple regression analyses, which tested the hypothesis that haplogroup D-M55 predicts BMI and perceived number of close friends, confirmed our hypothesis, even after controlling for the potentially confounding variables of age and sex. We also analyzed the gene–gene interaction between haplogroup D-M55 and an autosomal gene polymorphism associated with BMI and human relationships, such as the dopamine D2 receptor gene (DRD2: rs1800497). Results showed gene–gene interactions between haplogroups D-M55 and DRD2 in BMI. Based on these findings, it is demonstrated that Y-DNA haplogroup D is associated with human personality.
format	article
author	Masahiro Matsunaga Yohsuke Ohtsubo Takahiko Masuda Yasuki Noguchi Hidenori Yamasue Keiko Ishii
author_facet	Masahiro Matsunaga Yohsuke Ohtsubo Takahiko Masuda Yasuki Noguchi Hidenori Yamasue Keiko Ishii
author_sort	Masahiro Matsunaga
title	A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics
title_short	A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics
title_full	A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics
title_fullStr	A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics
title_full_unstemmed	A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics
title_sort	genetic variation in the y chromosome among modern japanese males related to several physiological and psychological characteristics
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/906360b2cb6e4606b9d23c93538d6ee4
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A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics

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