Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

Light-sheet microscopes are increasingly used for imaging cleared tissues, but have imposed constraints on sample geometries and protocols. Here the authors present a multi-immersion open-top light-sheet microscope to overcome these limitations and enable high-throughput imaging of samples processed...

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Autores principales:	Adam K. Glaser, Nicholas P. Reder, Ye Chen, Chengbo Yin, Linpeng Wei, Soyoung Kang, Lindsey A. Barner, Weisi Xie, Erin F. McCarty, Chenyi Mao, Aaron R. Halpern, Caleb R. Stoltzfus, Jonathan S. Daniels, Michael Y. Gerner, Philip R. Nicovich, Joshua C. Vaughan, Lawrence D. True, Jonathan T. C. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90636626e5c14c7aacc695bf6808696a
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spelling	oai:doaj.org-article:90636626e5c14c7aacc695bf6808696a2021-12-02T15:36:22ZMulti-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues10.1038/s41467-019-10534-02041-1723https://doaj.org/article/90636626e5c14c7aacc695bf6808696a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10534-0https://doaj.org/toc/2041-1723Light-sheet microscopes are increasingly used for imaging cleared tissues, but have imposed constraints on sample geometries and protocols. Here the authors present a multi-immersion open-top light-sheet microscope to overcome these limitations and enable high-throughput imaging of samples processed with various clearing protocols.Adam K. GlaserNicholas P. RederYe ChenChengbo YinLinpeng WeiSoyoung KangLindsey A. BarnerWeisi XieErin F. McCartyChenyi MaoAaron R. HalpernCaleb R. StoltzfusJonathan S. DanielsMichael Y. GernerPhilip R. NicovichJoshua C. VaughanLawrence D. TrueJonathan T. C. LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam K. Glaser Nicholas P. Reder Ye Chen Chengbo Yin Linpeng Wei Soyoung Kang Lindsey A. Barner Weisi Xie Erin F. McCarty Chenyi Mao Aaron R. Halpern Caleb R. Stoltzfus Jonathan S. Daniels Michael Y. Gerner Philip R. Nicovich Joshua C. Vaughan Lawrence D. True Jonathan T. C. Liu Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
description	Light-sheet microscopes are increasingly used for imaging cleared tissues, but have imposed constraints on sample geometries and protocols. Here the authors present a multi-immersion open-top light-sheet microscope to overcome these limitations and enable high-throughput imaging of samples processed with various clearing protocols.
format	article
author	Adam K. Glaser Nicholas P. Reder Ye Chen Chengbo Yin Linpeng Wei Soyoung Kang Lindsey A. Barner Weisi Xie Erin F. McCarty Chenyi Mao Aaron R. Halpern Caleb R. Stoltzfus Jonathan S. Daniels Michael Y. Gerner Philip R. Nicovich Joshua C. Vaughan Lawrence D. True Jonathan T. C. Liu
author_facet	Adam K. Glaser Nicholas P. Reder Ye Chen Chengbo Yin Linpeng Wei Soyoung Kang Lindsey A. Barner Weisi Xie Erin F. McCarty Chenyi Mao Aaron R. Halpern Caleb R. Stoltzfus Jonathan S. Daniels Michael Y. Gerner Philip R. Nicovich Joshua C. Vaughan Lawrence D. True Jonathan T. C. Liu
author_sort	Adam K. Glaser
title	Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
title_short	Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
title_full	Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
title_fullStr	Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
title_full_unstemmed	Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
title_sort	multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/90636626e5c14c7aacc695bf6808696a
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Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

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