The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.

Aging is associated with functional decline in the immune system and increases the risk of chronic diseases owing to smoldering inflammation. In the present study, we demonstrated an age-related increase in the accumulation of Programmed Death-1 (PD-1)+ memory-phenotype T cells that are considered &...

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Autores principales:	Xiaoxiang Yan, Natsumi Imano, Kayoko Tamaki, Motoaki Sano, Ken Shinmura
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9064f5ea30f0455c845f8156f8cbc8be
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spelling	oai:doaj.org-article:9064f5ea30f0455c845f8156f8cbc8be2021-12-02T20:07:06ZThe effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.1932-620310.1371/journal.pone.0252547https://doaj.org/article/9064f5ea30f0455c845f8156f8cbc8be2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252547https://doaj.org/toc/1932-6203Aging is associated with functional decline in the immune system and increases the risk of chronic diseases owing to smoldering inflammation. In the present study, we demonstrated an age-related increase in the accumulation of Programmed Death-1 (PD-1)+ memory-phenotype T cells that are considered "senescence-associated T cells" in both the visceral adipose tissue and spleen. As caloric restriction is an established intervention scientifically proven to exert anti-aging effects and greatly affects physiological and pathophysiological alterations with advanced age, we evaluated the effect of caloric restriction on the increase in this T-cell subpopulation and glucose tolerance in aged mice. Long-term caloric restriction significantly decreased the number of PD-1+ memory-phenotype cluster of differentiation (CD) 4+ and CD8+ T cells in the spleen and visceral adipose tissue, decreased M1-type macrophage accumulation in visceral adipose tissue, and improved insulin resistance in aged mice. Furthermore, the immunological depletion of PD-1+ T cells reduced adipose inflammation and improved insulin resistance in aged mice. Taken together with our previous report, these results indicate that senescence-related T-cell subpopulations are involved in the development of chronic inflammation and insulin resistance in the context of chronological aging and obesity. Thus, long-term caloric restriction and specific deletion of senescence-related T cells are promising interventions to regulate age-related chronic diseases.Xiaoxiang YanNatsumi ImanoKayoko TamakiMotoaki SanoKen ShinmuraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252547 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoxiang Yan Natsumi Imano Kayoko Tamaki Motoaki Sano Ken Shinmura The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
description	Aging is associated with functional decline in the immune system and increases the risk of chronic diseases owing to smoldering inflammation. In the present study, we demonstrated an age-related increase in the accumulation of Programmed Death-1 (PD-1)+ memory-phenotype T cells that are considered "senescence-associated T cells" in both the visceral adipose tissue and spleen. As caloric restriction is an established intervention scientifically proven to exert anti-aging effects and greatly affects physiological and pathophysiological alterations with advanced age, we evaluated the effect of caloric restriction on the increase in this T-cell subpopulation and glucose tolerance in aged mice. Long-term caloric restriction significantly decreased the number of PD-1+ memory-phenotype cluster of differentiation (CD) 4+ and CD8+ T cells in the spleen and visceral adipose tissue, decreased M1-type macrophage accumulation in visceral adipose tissue, and improved insulin resistance in aged mice. Furthermore, the immunological depletion of PD-1+ T cells reduced adipose inflammation and improved insulin resistance in aged mice. Taken together with our previous report, these results indicate that senescence-related T-cell subpopulations are involved in the development of chronic inflammation and insulin resistance in the context of chronological aging and obesity. Thus, long-term caloric restriction and specific deletion of senescence-related T cells are promising interventions to regulate age-related chronic diseases.
format	article
author	Xiaoxiang Yan Natsumi Imano Kayoko Tamaki Motoaki Sano Ken Shinmura
author_facet	Xiaoxiang Yan Natsumi Imano Kayoko Tamaki Motoaki Sano Ken Shinmura
author_sort	Xiaoxiang Yan
title	The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
title_short	The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
title_full	The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
title_fullStr	The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
title_full_unstemmed	The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
title_sort	effect of caloric restriction on the increase in senescence-associated t cells and metabolic disorders in aged mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9064f5ea30f0455c845f8156f8cbc8be
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The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.

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