Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation

Abstract Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD). It is a challenge to identify environmental factors such as diet that may be driving this risk. Intestinal fibrosis result from accumulation of extracellular matrix (ECM) proteins secreted by myofibroblasts...

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Autores principales:	Asma Amamou, Matthieu Rouland, Linda Yaker, Alexis Goichon, Charlène Guérin, Moutaz Aziz, Guillaume Savoye, Rachel Marion-Letellier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/906505c9f45b4ec199e6c7a0a4f07733
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spelling	oai:doaj.org-article:906505c9f45b4ec199e6c7a0a4f077332021-12-02T17:55:09ZDietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation10.1038/s41598-021-94280-82045-2322https://doaj.org/article/906505c9f45b4ec199e6c7a0a4f077332021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94280-8https://doaj.org/toc/2045-2322Abstract Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD). It is a challenge to identify environmental factors such as diet that may be driving this risk. Intestinal fibrosis result from accumulation of extracellular matrix (ECM) proteins secreted by myofibroblasts. Factors promoting intestinal fibrosis are unknown, but diet appears to be a critical component in its development. Consumption of salt above nutritional recommendations can exacerbate chronic inflammation. So far, high salt diet (HSD) have not been thoroughly investigated in the context of intestinal fibrosis associated to IBD. In the present study, we analyze the role of dietary salt in TNBS chronic colitis induced in rat, an intestinal fibrosis model, or in human colon fibroblast cells. Here, we have shown that high-salt diet exacerbates undernutrition and promoted ECM-associated proteins in fibroblasts. Taken together, our results suggested that dietary salt can activate intestinal fibroblasts, thereby contributing to exacerbation of intestinal fibrosis. Dietary salt may be considered as a putative environmental factor that drives intestinal fibrosis risk.Asma AmamouMatthieu RoulandLinda YakerAlexis GoichonCharlène GuérinMoutaz AzizGuillaume SavoyeRachel Marion-LetellierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asma Amamou Matthieu Rouland Linda Yaker Alexis Goichon Charlène Guérin Moutaz Aziz Guillaume Savoye Rachel Marion-Letellier Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
description	Abstract Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD). It is a challenge to identify environmental factors such as diet that may be driving this risk. Intestinal fibrosis result from accumulation of extracellular matrix (ECM) proteins secreted by myofibroblasts. Factors promoting intestinal fibrosis are unknown, but diet appears to be a critical component in its development. Consumption of salt above nutritional recommendations can exacerbate chronic inflammation. So far, high salt diet (HSD) have not been thoroughly investigated in the context of intestinal fibrosis associated to IBD. In the present study, we analyze the role of dietary salt in TNBS chronic colitis induced in rat, an intestinal fibrosis model, or in human colon fibroblast cells. Here, we have shown that high-salt diet exacerbates undernutrition and promoted ECM-associated proteins in fibroblasts. Taken together, our results suggested that dietary salt can activate intestinal fibroblasts, thereby contributing to exacerbation of intestinal fibrosis. Dietary salt may be considered as a putative environmental factor that drives intestinal fibrosis risk.
format	article
author	Asma Amamou Matthieu Rouland Linda Yaker Alexis Goichon Charlène Guérin Moutaz Aziz Guillaume Savoye Rachel Marion-Letellier
author_facet	Asma Amamou Matthieu Rouland Linda Yaker Alexis Goichon Charlène Guérin Moutaz Aziz Guillaume Savoye Rachel Marion-Letellier
author_sort	Asma Amamou
title	Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
title_short	Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
title_full	Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
title_fullStr	Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
title_full_unstemmed	Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
title_sort	dietary salt exacerbates intestinal fibrosis in chronic tnbs colitis via fibroblasts activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/906505c9f45b4ec199e6c7a0a4f07733
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Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation

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