Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A <italic toggle="yes">Streptococcus</italic>

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Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A <italic toggle="yes">Streptococcus</italic>

ABSTRACT Streptococcus pyogenes (group A Streptococcus [GAS]) causes ~700 million human infections/year, resulting in >500,000 deaths. There is no commercial GAS vaccine available. The GAS surface protein arginine deiminase (ADI) protects mice against a lethal challenge. ADI is an enzyme that con...

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Bibliographic Details
Main Authors:	Anna Henningham, Daniel J. Ericsson, Karla Langer, Lachlan W. Casey, Blagojce Jovcevski, G. Singh Chhatwal, J. Andrew Aquilina, Michael R. Batzloff, Bostjan Kobe, Mark J. Walker
Format:	article
Language:	EN
Published:	American Society for Microbiology 2013
Subjects:	Microbiology QR1-502
Online Access:	https://doaj.org/article/90669fba22484c2091bf8b72cdcee539
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