Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

Skeletal muscle is composed of syncytial myofibres, each containing hundreds of nuclei. Through genetic reduction of the number of nuclei per myofibre, the authors confirm that more nuclei produce larger cells but myofibres with fewer nuclei adaptively compensate leading to larger and functional myo...

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Autores principales:	Alyssa A. W. Cramer, Vikram Prasad, Einar Eftestøl, Taejeong Song, Kenth-Arne Hansson, Hannah F. Dugdale, Sakthivel Sadayappan, Julien Ochala, Kristian Gundersen, Douglas P. Millay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/906853b2f23840218061a82cb85c451a
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spelling	oai:doaj.org-article:906853b2f23840218061a82cb85c451a2021-12-02T14:16:40ZNuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains10.1038/s41467-020-20058-72041-1723https://doaj.org/article/906853b2f23840218061a82cb85c451a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20058-7https://doaj.org/toc/2041-1723Skeletal muscle is composed of syncytial myofibres, each containing hundreds of nuclei. Through genetic reduction of the number of nuclei per myofibre, the authors confirm that more nuclei produce larger cells but myofibres with fewer nuclei adaptively compensate leading to larger and functional myonuclear domains.Alyssa A. W. CramerVikram PrasadEinar EftestølTaejeong SongKenth-Arne HanssonHannah F. DugdaleSakthivel SadayappanJulien OchalaKristian GundersenDouglas P. MillayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyssa A. W. Cramer Vikram Prasad Einar Eftestøl Taejeong Song Kenth-Arne Hansson Hannah F. Dugdale Sakthivel Sadayappan Julien Ochala Kristian Gundersen Douglas P. Millay Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
description	Skeletal muscle is composed of syncytial myofibres, each containing hundreds of nuclei. Through genetic reduction of the number of nuclei per myofibre, the authors confirm that more nuclei produce larger cells but myofibres with fewer nuclei adaptively compensate leading to larger and functional myonuclear domains.
format	article
author	Alyssa A. W. Cramer Vikram Prasad Einar Eftestøl Taejeong Song Kenth-Arne Hansson Hannah F. Dugdale Sakthivel Sadayappan Julien Ochala Kristian Gundersen Douglas P. Millay
author_facet	Alyssa A. W. Cramer Vikram Prasad Einar Eftestøl Taejeong Song Kenth-Arne Hansson Hannah F. Dugdale Sakthivel Sadayappan Julien Ochala Kristian Gundersen Douglas P. Millay
author_sort	Alyssa A. W. Cramer
title	Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
title_short	Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
title_full	Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
title_fullStr	Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
title_full_unstemmed	Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
title_sort	nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/906853b2f23840218061a82cb85c451a
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Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

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