The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which determines AML sensitivity to HDAC inhibitors.

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Autores principales: Ali Khateb, Anagha Deshpande, Yongmei Feng, Darren Finlay, Joo Sang Lee, Ikrame Lazar, Bertrand Fabre, Yan Li, Yu Fujita, Tongwu Zhang, Jun Yin, Ian Pass, Ido Livneh, Irmela Jeremias, Carol Burian, James R. Mason, Ronit Almog, Nurit Horesh, Yishai Ofran, Kevin Brown, Kristiina Vuori, Michael Jackson, Eytan Ruppin, Aniruddha J. Deshpande, Ze’ev A. Ronai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/906878f0ea8448bb9623f72fa90b2362
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spelling oai:doaj.org-article:906878f0ea8448bb9623f72fa90b23622021-12-02T17:25:34ZThe ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors10.1038/s41467-021-25664-72041-1723https://doaj.org/article/906878f0ea8448bb9623f72fa90b23622021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25664-7https://doaj.org/toc/2041-1723Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which determines AML sensitivity to HDAC inhibitors.Ali KhatebAnagha DeshpandeYongmei FengDarren FinlayJoo Sang LeeIkrame LazarBertrand FabreYan LiYu FujitaTongwu ZhangJun YinIan PassIdo LivnehIrmela JeremiasCarol BurianJames R. MasonRonit AlmogNurit HoreshYishai OfranKevin BrownKristiina VuoriMichael JacksonEytan RuppinAniruddha J. DeshpandeZe’ev A. RonaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ali Khateb
Anagha Deshpande
Yongmei Feng
Darren Finlay
Joo Sang Lee
Ikrame Lazar
Bertrand Fabre
Yan Li
Yu Fujita
Tongwu Zhang
Jun Yin
Ian Pass
Ido Livneh
Irmela Jeremias
Carol Burian
James R. Mason
Ronit Almog
Nurit Horesh
Yishai Ofran
Kevin Brown
Kristiina Vuori
Michael Jackson
Eytan Ruppin
Aniruddha J. Deshpande
Ze’ev A. Ronai
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
description Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which determines AML sensitivity to HDAC inhibitors.
format article
author Ali Khateb
Anagha Deshpande
Yongmei Feng
Darren Finlay
Joo Sang Lee
Ikrame Lazar
Bertrand Fabre
Yan Li
Yu Fujita
Tongwu Zhang
Jun Yin
Ian Pass
Ido Livneh
Irmela Jeremias
Carol Burian
James R. Mason
Ronit Almog
Nurit Horesh
Yishai Ofran
Kevin Brown
Kristiina Vuori
Michael Jackson
Eytan Ruppin
Aniruddha J. Deshpande
Ze’ev A. Ronai
author_facet Ali Khateb
Anagha Deshpande
Yongmei Feng
Darren Finlay
Joo Sang Lee
Ikrame Lazar
Bertrand Fabre
Yan Li
Yu Fujita
Tongwu Zhang
Jun Yin
Ian Pass
Ido Livneh
Irmela Jeremias
Carol Burian
James R. Mason
Ronit Almog
Nurit Horesh
Yishai Ofran
Kevin Brown
Kristiina Vuori
Michael Jackson
Eytan Ruppin
Aniruddha J. Deshpande
Ze’ev A. Ronai
author_sort Ali Khateb
title The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
title_short The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
title_full The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
title_fullStr The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
title_full_unstemmed The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
title_sort ubiquitin ligase rnf5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/906878f0ea8448bb9623f72fa90b2362
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