EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS

Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in co...

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Auteurs principaux:	Tayyaba Faisal, Khadija Qamar, Rafia Asjid, Faiza Umbreen, Saima Sohail, Sumayya Bashir
Format:	article
Langue:	EN
Publié:	Army Medical College Rawalpindi 2019
Sujets:	achilles tendon enthesis collagen fibers Medicine R Medicine (General) R5-920
Accès en ligne:	https://doaj.org/article/9068a20b54884eebaf8aa619dcc57b8f
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spelling	oai:doaj.org-article:9068a20b54884eebaf8aa619dcc57b8f2021-11-12T06:10:51ZEFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS0030-96482411-8842https://doaj.org/article/9068a20b54884eebaf8aa619dcc57b8f2019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2734/2142https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. Material and Methods: Forty, healthy, male, “New Zealand white rabbits”, 4-6 months of age, weighing 2000- 2500g, were randomly divided into 4 equal groups (A, B, C and D). Group A served as control, while B, C and D were experimental groups. Injuries were surgically induced at Achilles tendon entheses of rabbits of experimental groups, which were treated with injections of autologous platelet-rich plasma, either at the time of inducing injury or two weeks after injury in groups C and D respectively while group B was left untreated. Animals were sacrificed after 12 weeks. Tissues were processed and stained for histological evaluation. Statistical analysis was done using SPSS version 22. A p-value of ≤0.05 was taken as significant. Results: Experimental group B showed marked deterioration in Bonar’s modified score for arrangement of collagen fibers as compared to the control group A. The scores were significantly improved in treatment groups C and D as compared to group B. Conclusions: Injection of autologous platelet-rich plasma effectively improved the Bonar modified score for arrangement of collagen fibers at injured entheses, 12 weeks after injury as compared to non-treatment group.Tayyaba FaisalKhadija QamarRafia AsjidFaiza UmbreenSaima SohailSumayya BashirArmy Medical College Rawalpindiarticleachilles tendon enthesiscollagen fibersMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 2, Pp 262-267 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	achilles tendon enthesis collagen fibers Medicine R Medicine (General) R5-920
spellingShingle	achilles tendon enthesis collagen fibers Medicine R Medicine (General) R5-920 Tayyaba Faisal Khadija Qamar Rafia Asjid Faiza Umbreen Saima Sohail Sumayya Bashir EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS
description	Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. Material and Methods: Forty, healthy, male, “New Zealand white rabbits”, 4-6 months of age, weighing 2000- 2500g, were randomly divided into 4 equal groups (A, B, C and D). Group A served as control, while B, C and D were experimental groups. Injuries were surgically induced at Achilles tendon entheses of rabbits of experimental groups, which were treated with injections of autologous platelet-rich plasma, either at the time of inducing injury or two weeks after injury in groups C and D respectively while group B was left untreated. Animals were sacrificed after 12 weeks. Tissues were processed and stained for histological evaluation. Statistical analysis was done using SPSS version 22. A p-value of ≤0.05 was taken as significant. Results: Experimental group B showed marked deterioration in Bonar’s modified score for arrangement of collagen fibers as compared to the control group A. The scores were significantly improved in treatment groups C and D as compared to group B. Conclusions: Injection of autologous platelet-rich plasma effectively improved the Bonar modified score for arrangement of collagen fibers at injured entheses, 12 weeks after injury as compared to non-treatment group.
format	article
author	Tayyaba Faisal Khadija Qamar Rafia Asjid Faiza Umbreen Saima Sohail Sumayya Bashir
author_facet	Tayyaba Faisal Khadija Qamar Rafia Asjid Faiza Umbreen Saima Sohail Sumayya Bashir
author_sort	Tayyaba Faisal
title	EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS
title_short	EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS
title_full	EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS
title_fullStr	EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS
title_full_unstemmed	EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS
title_sort	effect of autologous platelet-rich plasma on arrangement of collagen fibers at injured achilles tendon entheses in rabbits
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/9068a20b54884eebaf8aa619dcc57b8f
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EFFECT OF AUTOLOGOUS PLATELET-RICH PLASMA ON ARRANGEMENT OF COLLAGEN FIBERS AT INJURED ACHILLES TENDON ENTHESES IN RABBITS

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