Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.

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Autores principales:	Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, Yan Xu, Ronald A. Conlon, Sanford Markowitz, Kenneth W. Kinzler, Victor E. Velculescu, Henri Brunengraber, Joseph E. Willis, Thomas LaFramboise, Maria Hatzoglou, Guo-Fang Zhang, Bert Vogelstein, Zhenghe Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/906e6679c4cc4a669a5f8d6f4ee9c634
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:906e6679c4cc4a669a5f8d6f4ee9c6342021-12-02T15:35:24ZOncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer10.1038/ncomms119712041-1723https://doaj.org/article/906e6679c4cc4a669a5f8d6f4ee9c6342016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11971https://doaj.org/toc/2041-1723Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.Yujun HaoYardena SamuelsQingling LiDawid KrokowskiBo-Jhih GuanChao WangZhicheng JinBohan DongBo CaoXiujing FengMin XiangClaire XuStephen FinkNeal J. MeropolYan XuRonald A. ConlonSanford MarkowitzKenneth W. KinzlerVictor E. VelculescuHenri BrunengraberJoseph E. WillisThomas LaFramboiseMaria HatzoglouGuo-Fang ZhangBert VogelsteinZhenghe WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yujun Hao Yardena Samuels Qingling Li Dawid Krokowski Bo-Jhih Guan Chao Wang Zhicheng Jin Bohan Dong Bo Cao Xiujing Feng Min Xiang Claire Xu Stephen Fink Neal J. Meropol Yan Xu Ronald A. Conlon Sanford Markowitz Kenneth W. Kinzler Victor E. Velculescu Henri Brunengraber Joseph E. Willis Thomas LaFramboise Maria Hatzoglou Guo-Fang Zhang Bert Vogelstein Zhenghe Wang Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
description	Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.
format	article
author	Yujun Hao Yardena Samuels Qingling Li Dawid Krokowski Bo-Jhih Guan Chao Wang Zhicheng Jin Bohan Dong Bo Cao Xiujing Feng Min Xiang Claire Xu Stephen Fink Neal J. Meropol Yan Xu Ronald A. Conlon Sanford Markowitz Kenneth W. Kinzler Victor E. Velculescu Henri Brunengraber Joseph E. Willis Thomas LaFramboise Maria Hatzoglou Guo-Fang Zhang Bert Vogelstein Zhenghe Wang
author_facet	Yujun Hao Yardena Samuels Qingling Li Dawid Krokowski Bo-Jhih Guan Chao Wang Zhicheng Jin Bohan Dong Bo Cao Xiujing Feng Min Xiang Claire Xu Stephen Fink Neal J. Meropol Yan Xu Ronald A. Conlon Sanford Markowitz Kenneth W. Kinzler Victor E. Velculescu Henri Brunengraber Joseph E. Willis Thomas LaFramboise Maria Hatzoglou Guo-Fang Zhang Bert Vogelstein Zhenghe Wang
author_sort	Yujun Hao
title	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
title_short	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
title_full	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
title_fullStr	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
title_full_unstemmed	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
title_sort	oncogenic pik3ca mutations reprogram glutamine metabolism in colorectal cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/906e6679c4cc4a669a5f8d6f4ee9c634
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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

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