Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment

Abstract Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a major cause of morbidity and mortality in elderly and postmenopausal adults, posing a...

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Autores principales:	Xiao-Yu He, Hai-Ming Yu, Shu Lin, Yi-Zhong Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mesenchymal stem cell Exosome Biomimetic materials 3D printing Osteoporosis Cytology QH573-671
Acceso en línea:	https://doaj.org/article/907181b7e12d419c9076f76145f4de9c
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spelling	oai:doaj.org-article:907181b7e12d419c9076f76145f4de9c2021-11-21T12:06:38ZAdvances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment10.1186/s11658-021-00291-81425-81531689-1392https://doaj.org/article/907181b7e12d419c9076f76145f4de9c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s11658-021-00291-8https://doaj.org/toc/1425-8153https://doaj.org/toc/1689-1392Abstract Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a major cause of morbidity and mortality in elderly and postmenopausal adults, posing a considerable socioeconomic burden. However, existing treatments can only slow down the process of osteoporosis, reduce the risk of fractures, and repair fractures locally. Therefore, emerging methods for treating osteoporosis, such as mesenchymal stem cell transplantation, exosome-driving drug delivery systems, biomimetic materials, and 3D printing technology, have received increasing research attention, with significant progress. Mesenchymal stem cells (MSCs) are pluripotent stem cells that can differentiate into different types of functional cells. Exosomes play a key role in regulating cell microenvironments through paracrine mechanisms. Bionic materials and 3D printed scaffolds are beneficial for the reconstruction and repair of osteoporotic bones and osteoporosis-related fractures. Stem cells, exosomes, and biomimetic materials represent emerging technologies for osteoporosis treatment. This review summarizes the latest developments in these three aspects.Xiao-Yu HeHai-Ming YuShu LinYi-Zhong LiBMCarticleMesenchymal stem cellExosomeBiomimetic materials3D printingOsteoporosisCytologyQH573-671ENCellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesenchymal stem cell Exosome Biomimetic materials 3D printing Osteoporosis Cytology QH573-671
spellingShingle	Mesenchymal stem cell Exosome Biomimetic materials 3D printing Osteoporosis Cytology QH573-671 Xiao-Yu He Hai-Ming Yu Shu Lin Yi-Zhong Li Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment
description	Abstract Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a major cause of morbidity and mortality in elderly and postmenopausal adults, posing a considerable socioeconomic burden. However, existing treatments can only slow down the process of osteoporosis, reduce the risk of fractures, and repair fractures locally. Therefore, emerging methods for treating osteoporosis, such as mesenchymal stem cell transplantation, exosome-driving drug delivery systems, biomimetic materials, and 3D printing technology, have received increasing research attention, with significant progress. Mesenchymal stem cells (MSCs) are pluripotent stem cells that can differentiate into different types of functional cells. Exosomes play a key role in regulating cell microenvironments through paracrine mechanisms. Bionic materials and 3D printed scaffolds are beneficial for the reconstruction and repair of osteoporotic bones and osteoporosis-related fractures. Stem cells, exosomes, and biomimetic materials represent emerging technologies for osteoporosis treatment. This review summarizes the latest developments in these three aspects.
format	article
author	Xiao-Yu He Hai-Ming Yu Shu Lin Yi-Zhong Li
author_facet	Xiao-Yu He Hai-Ming Yu Shu Lin Yi-Zhong Li
author_sort	Xiao-Yu He
title	Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment
title_short	Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment
title_full	Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment
title_fullStr	Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment
title_full_unstemmed	Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment
title_sort	advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3d printing in osteoporosis treatment
publisher	BMC
publishDate	2021
url	https://doaj.org/article/907181b7e12d419c9076f76145f4de9c
work_keys_str_mv	AT xiaoyuhe advancesintheapplicationofmesenchymalstemcellsexosomesbiomimeticmaterialsand3dprintinginosteoporosistreatment AT haimingyu advancesintheapplicationofmesenchymalstemcellsexosomesbiomimeticmaterialsand3dprintinginosteoporosistreatment AT shulin advancesintheapplicationofmesenchymalstemcellsexosomesbiomimeticmaterialsand3dprintinginosteoporosistreatment AT yizhongli advancesintheapplicationofmesenchymalstemcellsexosomesbiomimeticmaterialsand3dprintinginosteoporosistreatment
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Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment

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