Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and glucose tolerance in mouse models.
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Nature Portfolio
2017
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oai:doaj.org-article:9072caa59698443ba30fe40fdc34e5b32021-12-02T14:42:42ZSelenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models10.1038/s41467-017-01863-z2041-1723https://doaj.org/article/9072caa59698443ba30fe40fdc34e5b32017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01863-zhttps://doaj.org/toc/2041-1723Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and glucose tolerance in mouse models.Yuichiro MitaKaho NakayamaShogo InariYukina NishitoYuya YoshiokaNaoko SakaiKanade SotaniTakahiro NagamuraYuki KuzuharaKumi InagakiMiki IwasakiHirofumi MisuMasaya IkegawaToshinari TakamuraNoriko NoguchiYoshiro SaitoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yuichiro Mita Kaho Nakayama Shogo Inari Yukina Nishito Yuya Yoshioka Naoko Sakai Kanade Sotani Takahiro Nagamura Yuki Kuzuhara Kumi Inagaki Miki Iwasaki Hirofumi Misu Masaya Ikegawa Toshinari Takamura Noriko Noguchi Yoshiro Saito Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| description |
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and glucose tolerance in mouse models. |
| format |
article |
| author |
Yuichiro Mita Kaho Nakayama Shogo Inari Yukina Nishito Yuya Yoshioka Naoko Sakai Kanade Sotani Takahiro Nagamura Yuki Kuzuhara Kumi Inagaki Miki Iwasaki Hirofumi Misu Masaya Ikegawa Toshinari Takamura Noriko Noguchi Yoshiro Saito |
| author_facet |
Yuichiro Mita Kaho Nakayama Shogo Inari Yukina Nishito Yuya Yoshioka Naoko Sakai Kanade Sotani Takahiro Nagamura Yuki Kuzuhara Kumi Inagaki Miki Iwasaki Hirofumi Misu Masaya Ikegawa Toshinari Takamura Noriko Noguchi Yoshiro Saito |
| author_sort |
Yuichiro Mita |
| title |
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| title_short |
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| title_full |
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| title_fullStr |
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| title_full_unstemmed |
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| title_sort |
selenoprotein p-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/9072caa59698443ba30fe40fdc34e5b3 |
| work_keys_str_mv |
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