Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and glucose tolerance in mouse models.
Guardado en:
Autores principales: | Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/9072caa59698443ba30fe40fdc34e5b3 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery
por: Didac Santesmasses, et al.
Publicado: (2021) -
Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P
por: Kostja Renko, et al.
Publicado: (2017) -
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
por: Hyunsoo Kim, et al.
Publicado: (2021) -
Delayed Respiratory Insufficiency and Extramuscular Abnormalities in Selenoprotein N-Related Myopathies
por: Shu Zhang, et al.
Publicado: (2021) -
Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients.
por: Hellmuth A Meyer, et al.
Publicado: (2012)