Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations

Kv1.2 is a voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. Here authors use electrophysiology and find that Slc7a5, a neutral amino acid transporter, has a profound impact on Kv1.2.

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Autores principales:	Victoria A. Baronas, Runying Y. Yang, Luis Carlos Morales, Simonetta Sipione, Harley T. Kurata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9072db4f46694f3682961e93260652af
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spelling	oai:doaj.org-article:9072db4f46694f3682961e93260652af2021-12-02T14:39:44ZSlc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations10.1038/s41467-018-06859-x2041-1723https://doaj.org/article/9072db4f46694f3682961e93260652af2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06859-xhttps://doaj.org/toc/2041-1723Kv1.2 is a voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. Here authors use electrophysiology and find that Slc7a5, a neutral amino acid transporter, has a profound impact on Kv1.2.Victoria A. BaronasRunying Y. YangLuis Carlos MoralesSimonetta SipioneHarley T. KurataNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victoria A. Baronas Runying Y. Yang Luis Carlos Morales Simonetta Sipione Harley T. Kurata Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
description	Kv1.2 is a voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. Here authors use electrophysiology and find that Slc7a5, a neutral amino acid transporter, has a profound impact on Kv1.2.
format	article
author	Victoria A. Baronas Runying Y. Yang Luis Carlos Morales Simonetta Sipione Harley T. Kurata
author_facet	Victoria A. Baronas Runying Y. Yang Luis Carlos Morales Simonetta Sipione Harley T. Kurata
author_sort	Victoria A. Baronas
title	Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
title_short	Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
title_full	Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
title_fullStr	Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
title_full_unstemmed	Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
title_sort	slc7a5 regulates kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9072db4f46694f3682961e93260652af
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Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations

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