Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography

Abstract This study aimed to investigate the clinicopathological and radiological significance of the collateral vessel of renal cell carcinoma (RCC) on preoperative computed tomography (CT). Preoperative contrast-enhanced CT of 236 consecutive patients with pathological documented RCC were retrospe...

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Autores principales:	Xueling Suo, Junru Chen, Yijun Zhao, Qidun Tang, Xibiao Yang, Yuan Yuan, Ling Nie, Ni Chen, Hao Zeng, Jin Yao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/907a7875124f4b8fbd2ceafa52afa06d
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spelling	oai:doaj.org-article:907a7875124f4b8fbd2ceafa52afa06d2021-12-02T13:34:57ZClinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography10.1038/s41598-021-84631-w2045-2322https://doaj.org/article/907a7875124f4b8fbd2ceafa52afa06d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84631-whttps://doaj.org/toc/2045-2322Abstract This study aimed to investigate the clinicopathological and radiological significance of the collateral vessel of renal cell carcinoma (RCC) on preoperative computed tomography (CT). Preoperative contrast-enhanced CT of 236 consecutive patients with pathological documented RCC were retrospectively reviewed during the period of 2014. The associations of the presence of collateral vessels with perioperative clinicopathological and radiological features, as well as long term survival outcomes were analyzed. Totally, collateral vessels were detected by contrast-enhanced CT in 110 of 236 patients. The presence of collateral vessels was significantly associated with higher pathologic T stage, higher Fuhrman grade, higher overall RENAL scores, greater tumor size and enhancement, and more tumor necrosis (all P < 0.05). In patients with clear cell RCC, those harboring collateral vessels had significantly higher SSIGN scores (P < 0.001) and shorter overall survival (P = 0.01) than those without collateral vessel. The incidence of intraoperative blood loss, blood transfusion, radical nephrectomy (RN) and open surgery were also significantly higher in patients with collateral vessels (all P < 0.05). In multivariate analysis, the presence of collateral vessels was significantly associated with RN (P = 0.021) and open surgery (P = 0.012). The presence of collateral vessels was significantly associated with aggressive clinicopathological parameters and worse prognosis. It is worth paying attention to its association with the choice of RN and open surgery in clinical practice.Xueling SuoJunru ChenYijun ZhaoQidun TangXibiao YangYuan YuanLing NieNi ChenHao ZengJin YaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueling Suo Junru Chen Yijun Zhao Qidun Tang Xibiao Yang Yuan Yuan Ling Nie Ni Chen Hao Zeng Jin Yao Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
description	Abstract This study aimed to investigate the clinicopathological and radiological significance of the collateral vessel of renal cell carcinoma (RCC) on preoperative computed tomography (CT). Preoperative contrast-enhanced CT of 236 consecutive patients with pathological documented RCC were retrospectively reviewed during the period of 2014. The associations of the presence of collateral vessels with perioperative clinicopathological and radiological features, as well as long term survival outcomes were analyzed. Totally, collateral vessels were detected by contrast-enhanced CT in 110 of 236 patients. The presence of collateral vessels was significantly associated with higher pathologic T stage, higher Fuhrman grade, higher overall RENAL scores, greater tumor size and enhancement, and more tumor necrosis (all P < 0.05). In patients with clear cell RCC, those harboring collateral vessels had significantly higher SSIGN scores (P < 0.001) and shorter overall survival (P = 0.01) than those without collateral vessel. The incidence of intraoperative blood loss, blood transfusion, radical nephrectomy (RN) and open surgery were also significantly higher in patients with collateral vessels (all P < 0.05). In multivariate analysis, the presence of collateral vessels was significantly associated with RN (P = 0.021) and open surgery (P = 0.012). The presence of collateral vessels was significantly associated with aggressive clinicopathological parameters and worse prognosis. It is worth paying attention to its association with the choice of RN and open surgery in clinical practice.
format	article
author	Xueling Suo Junru Chen Yijun Zhao Qidun Tang Xibiao Yang Yuan Yuan Ling Nie Ni Chen Hao Zeng Jin Yao
author_facet	Xueling Suo Junru Chen Yijun Zhao Qidun Tang Xibiao Yang Yuan Yuan Ling Nie Ni Chen Hao Zeng Jin Yao
author_sort	Xueling Suo
title	Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
title_short	Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
title_full	Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
title_fullStr	Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
title_full_unstemmed	Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
title_sort	clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/907a7875124f4b8fbd2ceafa52afa06d
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Clinicopathological and radiological significance of the collateral vessels of renal cell carcinoma on preoperative computed tomography

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