Circadian regulation of the Drosophila astrocyte transcriptome.

Recent studies have demonstrated that astrocytes cooperate with neurons of the brain to mediate circadian control of many rhythmic processes including locomotor activity and sleep. Transcriptional profiling studies have described the overall rhythmic landscape of the brain, but few have employed app...

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Autores principales:	Samantha You, Alder M Yu, Mary A Roberts, Ivanna J Joseph, F Rob Jackson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/907c60a3d5454f08ab1c50de388699c3
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spelling	oai:doaj.org-article:907c60a3d5454f08ab1c50de388699c32021-12-02T20:03:19ZCircadian regulation of the Drosophila astrocyte transcriptome.1553-73901553-740410.1371/journal.pgen.1009790https://doaj.org/article/907c60a3d5454f08ab1c50de388699c32021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009790https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Recent studies have demonstrated that astrocytes cooperate with neurons of the brain to mediate circadian control of many rhythmic processes including locomotor activity and sleep. Transcriptional profiling studies have described the overall rhythmic landscape of the brain, but few have employed approaches that reveal heterogeneous, cell-type specific rhythms of the brain. Using cell-specific isolation of ribosome-bound RNAs in Drosophila, we constructed the first circadian "translatome" for astrocytes. This analysis identified 293 "cycling genes" in astrocytes, most with mammalian orthologs. A subsequent behavioral genetic screen identified a number of genes whose expression is required in astrocytes for normal sleep behavior. In particular, we show that certain genes known to regulate fly innate immune responses are also required for normal sleep patterns.Samantha YouAlder M YuMary A RobertsIvanna J JosephF Rob JacksonPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 9, p e1009790 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Samantha You Alder M Yu Mary A Roberts Ivanna J Joseph F Rob Jackson Circadian regulation of the Drosophila astrocyte transcriptome.
description	Recent studies have demonstrated that astrocytes cooperate with neurons of the brain to mediate circadian control of many rhythmic processes including locomotor activity and sleep. Transcriptional profiling studies have described the overall rhythmic landscape of the brain, but few have employed approaches that reveal heterogeneous, cell-type specific rhythms of the brain. Using cell-specific isolation of ribosome-bound RNAs in Drosophila, we constructed the first circadian "translatome" for astrocytes. This analysis identified 293 "cycling genes" in astrocytes, most with mammalian orthologs. A subsequent behavioral genetic screen identified a number of genes whose expression is required in astrocytes for normal sleep behavior. In particular, we show that certain genes known to regulate fly innate immune responses are also required for normal sleep patterns.
format	article
author	Samantha You Alder M Yu Mary A Roberts Ivanna J Joseph F Rob Jackson
author_facet	Samantha You Alder M Yu Mary A Roberts Ivanna J Joseph F Rob Jackson
author_sort	Samantha You
title	Circadian regulation of the Drosophila astrocyte transcriptome.
title_short	Circadian regulation of the Drosophila astrocyte transcriptome.
title_full	Circadian regulation of the Drosophila astrocyte transcriptome.
title_fullStr	Circadian regulation of the Drosophila astrocyte transcriptome.
title_full_unstemmed	Circadian regulation of the Drosophila astrocyte transcriptome.
title_sort	circadian regulation of the drosophila astrocyte transcriptome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/907c60a3d5454f08ab1c50de388699c3
work_keys_str_mv	AT samanthayou circadianregulationofthedrosophilaastrocytetranscriptome AT aldermyu circadianregulationofthedrosophilaastrocytetranscriptome AT maryaroberts circadianregulationofthedrosophilaastrocytetranscriptome AT ivannajjoseph circadianregulationofthedrosophilaastrocytetranscriptome AT frobjackson circadianregulationofthedrosophilaastrocytetranscriptome
_version_	1718375672264523776

Circadian regulation of the Drosophila astrocyte transcriptome.

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