Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products

Irina Mirela Apetrei,1 Constantin Apetrei2 1Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, 2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, Galati, Romania Abstract:...

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Autores principales:	Apetrei IM, Apetrei C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	melatonin pharmaceutics graphene sensor cyclic voltammetry Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/907cdcb497a04114aa8c47d89abb8775
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spelling	oai:doaj.org-article:907cdcb497a04114aa8c47d89abb87752021-12-02T04:05:35ZVoltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products1178-2013https://doaj.org/article/907cdcb497a04114aa8c47d89abb87752016-05-01T00:00:00Zhttps://www.dovepress.com/voltammetric-determination-of-melatonin-using-a-graphene-based-sensor--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Irina Mirela Apetrei,1 Constantin Apetrei2 1Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, 2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, Galati, Romania Abstract: Melatonin can be sensitively detected in pharmaceuticals by cyclic voltammetry and fixed-potential amperometry using a graphene-based sensor. The sensor characterization of cyclic voltammetry constantly provides high values of electrode active area and heterogeneous rate constant. In optimal conditions, the sensor was applied for the determination of melatonin in different pharmaceutical samples. The sensitivity to melatonin was 0.0371 A M-1, and the limit of detection was 0.87×10-6 M. The data obtained by using the graphene-based sensor for the detection of melatonin in pharmaceutical products were in good agreement with the data provided by the producer. Since no interferences from the excipients were found, using a separation technique was not necessary. Additionally, the low price, ease of handling, small amount of sample, short time per analysis, and possibility of automation are the important advantages that recommend this methodology for quality control of pharmaceuticals. Keywords: electroanalysis, kinetics, chitosan, limit of detection, recoveryApetrei IMApetrei CDove Medical Pressarticlemelatoninpharmaceuticsgraphenesensorcyclic voltammetryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1859-1866 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	melatonin pharmaceutics graphene sensor cyclic voltammetry Medicine (General) R5-920
spellingShingle	melatonin pharmaceutics graphene sensor cyclic voltammetry Medicine (General) R5-920 Apetrei IM Apetrei C Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
description	Irina Mirela Apetrei,1 Constantin Apetrei2 1Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, 2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, Galati, Romania Abstract: Melatonin can be sensitively detected in pharmaceuticals by cyclic voltammetry and fixed-potential amperometry using a graphene-based sensor. The sensor characterization of cyclic voltammetry constantly provides high values of electrode active area and heterogeneous rate constant. In optimal conditions, the sensor was applied for the determination of melatonin in different pharmaceutical samples. The sensitivity to melatonin was 0.0371 A M-1, and the limit of detection was 0.87×10-6 M. The data obtained by using the graphene-based sensor for the detection of melatonin in pharmaceutical products were in good agreement with the data provided by the producer. Since no interferences from the excipients were found, using a separation technique was not necessary. Additionally, the low price, ease of handling, small amount of sample, short time per analysis, and possibility of automation are the important advantages that recommend this methodology for quality control of pharmaceuticals. Keywords: electroanalysis, kinetics, chitosan, limit of detection, recovery
format	article
author	Apetrei IM Apetrei C
author_facet	Apetrei IM Apetrei C
author_sort	Apetrei IM
title	Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
title_short	Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
title_full	Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
title_fullStr	Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
title_full_unstemmed	Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
title_sort	voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/907cdcb497a04114aa8c47d89abb8775
work_keys_str_mv	AT apetreiim voltammetricdeterminationofmelatoninusingagraphenebasedsensorinpharmaceuticalproducts AT apetreic voltammetricdeterminationofmelatoninusingagraphenebasedsensorinpharmaceuticalproducts
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Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products

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