Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Abstract Background The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture...

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Autores principales:	Ryusei Uchio, Kengo Kawasaki, Chinatsu Okuda-Hanafusa, Ryosuke Saji, Koutarou Muroyama, Shinji Murosaki, Yoshihiro Yamamoto, Yoshitaka Hirose
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Turmeric (Curcuma longa) Bisacurone Body mass index (BMI) Turmeronol Chronic inflammation C-reactive protein (CRP) Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/907e9aa1c93b419f96fd971887a84243
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spelling	oai:doaj.org-article:907e9aa1c93b419f96fd971887a842432021-11-14T12:10:38ZCurcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial10.1186/s12937-021-00748-81475-2891https://doaj.org/article/907e9aa1c93b419f96fd971887a842432021-11-01T00:00:00Zhttps://doi.org/10.1186/s12937-021-00748-8https://doaj.org/toc/1475-2891Abstract Background The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health. Methods We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05). Results After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score (p < 0.05). Conclusion CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance. Trial registration UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607Ryusei UchioKengo KawasakiChinatsu Okuda-HanafusaRyosuke SajiKoutarou MuroyamaShinji MurosakiYoshihiro YamamotoYoshitaka HiroseBMCarticleTurmeric (Curcuma longa)BisacuroneBody mass index (BMI)TurmeronolChronic inflammationC-reactive protein (CRP)Nutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENNutrition Journal, Vol 20, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Turmeric (Curcuma longa) Bisacurone Body mass index (BMI) Turmeronol Chronic inflammation C-reactive protein (CRP) Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Turmeric (Curcuma longa) Bisacurone Body mass index (BMI) Turmeronol Chronic inflammation C-reactive protein (CRP) Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Ryusei Uchio Kengo Kawasaki Chinatsu Okuda-Hanafusa Ryosuke Saji Koutarou Muroyama Shinji Murosaki Yoshihiro Yamamoto Yoshitaka Hirose Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
description	Abstract Background The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health. Methods We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05). Results After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score (p < 0.05). Conclusion CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance. Trial registration UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607
format	article
author	Ryusei Uchio Kengo Kawasaki Chinatsu Okuda-Hanafusa Ryosuke Saji Koutarou Muroyama Shinji Murosaki Yoshihiro Yamamoto Yoshitaka Hirose
author_facet	Ryusei Uchio Kengo Kawasaki Chinatsu Okuda-Hanafusa Ryosuke Saji Koutarou Muroyama Shinji Murosaki Yoshihiro Yamamoto Yoshitaka Hirose
author_sort	Ryusei Uchio
title	Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
title_short	Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
title_full	Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
title_fullStr	Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
title_full_unstemmed	Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
title_sort	curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/907e9aa1c93b419f96fd971887a84243
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Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

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