Inflammatory bowel disease: clinical aspects and treatments

Marc Fakhoury,1 Rebecca Negrulj,2 Armin Mooranian,2 Hani Al-Salami2 1Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, QC, Canada; 2Biotechnology and Dru...

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Autores principales:	Fakhoury M, Negrulj R, Mooranian A, Al-Salami H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/90850bf22a2745429eaad221be5035fe
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spelling	oai:doaj.org-article:90850bf22a2745429eaad221be5035fe2021-12-02T04:59:26ZInflammatory bowel disease: clinical aspects and treatments1178-7031https://doaj.org/article/90850bf22a2745429eaad221be5035fe2014-06-01T00:00:00Zhttp://www.dovepress.com/inflammatory-bowel-disease-clinical-aspects-and-treatments-a17319https://doaj.org/toc/1178-7031 Marc Fakhoury,1 Rebecca Negrulj,2 Armin Mooranian,2 Hani Al-Salami2 1Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, QC, Canada; 2Biotechnology and Drug Development Research Laboratory, Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University, Perth, WA, Australia Abstract: Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which elements of the digestive system are attacked by the body's own immune system. This inflammatory condition encompasses two major forms, known as Crohn's disease and ulcerative colitis. Patients affected by these diseases experience abdominal symptoms, including diarrhea, abdominal pain, bloody stools, and vomiting. Moreover, defects in intestinal epithelial barrier function have been observed in a number of patients affected by IBD. In this review, we first describe the types and symptoms of IBD and investigate the role that the epithelial barrier plays in the pathophysiology of IBD as well as the major cytokines involved. We then discuss steps used to diagnose this disease and the treatment options available, and finally provide an overview of the recent research that aims to develop new therapies for such chronic disorders. Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, cytokinesFakhoury MNegrulj RMooranian AAl-Salami HDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2014, Iss default, Pp 113-120 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Fakhoury M Negrulj R Mooranian A Al-Salami H Inflammatory bowel disease: clinical aspects and treatments
description	Marc Fakhoury,1 Rebecca Negrulj,2 Armin Mooranian,2 Hani Al-Salami2 1Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, QC, Canada; 2Biotechnology and Drug Development Research Laboratory, Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University, Perth, WA, Australia Abstract: Inflammatory bowel disease (IBD) is defined as a chronic intestinal inflammation that results from host-microbial interactions in a genetically susceptible individual. IBDs are a group of autoimmune diseases that are characterized by inflammation of both the small and large intestine, in which elements of the digestive system are attacked by the body's own immune system. This inflammatory condition encompasses two major forms, known as Crohn's disease and ulcerative colitis. Patients affected by these diseases experience abdominal symptoms, including diarrhea, abdominal pain, bloody stools, and vomiting. Moreover, defects in intestinal epithelial barrier function have been observed in a number of patients affected by IBD. In this review, we first describe the types and symptoms of IBD and investigate the role that the epithelial barrier plays in the pathophysiology of IBD as well as the major cytokines involved. We then discuss steps used to diagnose this disease and the treatment options available, and finally provide an overview of the recent research that aims to develop new therapies for such chronic disorders. Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, cytokines
format	article
author	Fakhoury M Negrulj R Mooranian A Al-Salami H
author_facet	Fakhoury M Negrulj R Mooranian A Al-Salami H
author_sort	Fakhoury M
title	Inflammatory bowel disease: clinical aspects and treatments
title_short	Inflammatory bowel disease: clinical aspects and treatments
title_full	Inflammatory bowel disease: clinical aspects and treatments
title_fullStr	Inflammatory bowel disease: clinical aspects and treatments
title_full_unstemmed	Inflammatory bowel disease: clinical aspects and treatments
title_sort	inflammatory bowel disease: clinical aspects and treatments
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/90850bf22a2745429eaad221be5035fe
work_keys_str_mv	AT fakhourym inflammatoryboweldiseaseclinicalaspectsandtreatments AT negruljr inflammatoryboweldiseaseclinicalaspectsandtreatments AT mooraniana inflammatoryboweldiseaseclinicalaspectsandtreatments AT alsalamih inflammatoryboweldiseaseclinicalaspectsandtreatments
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Inflammatory bowel disease: clinical aspects and treatments

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