Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.

<h4>Purpose</h4>To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hyp...

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Autores principales:	Richard Leigh, Shyian S Jen, Daniel D Varma, Argye E Hillis, Peter B Barker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9088b9e82ff447dbb7e98318e6d98b68
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spelling	oai:doaj.org-article:9088b9e82ff447dbb7e98318e6d98b682021-11-18T08:04:05ZArrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.1932-620310.1371/journal.pone.0052656https://doaj.org/article/9088b9e82ff447dbb7e98318e6d98b682012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285132/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hypoperfusion.<h4>Materials and methods</h4>A technique described in brain tumor patients was adapted to incorporate a correction for delayed contrast delivery due to perfusion deficits. This technique was applied to the MRIs of 9 stroke patients known to have blood-brain barrier (BBB) disruption on T1 post contrast imaging. Regions of BBB damage were compared with normal tissue from the contralateral hemisphere. Receiver operating characteristic (ROC) analysis was performed to compare the detection of BBB damage before and after ATC.<h4>Results</h4>ATC improved the area under the curve (AUC) of the ROC from 0.53 to 0.70. The sensitivity improved from 0.51 to 0.67 and the specificity improved from 0.57 to 0.66. Visual inspection of the ROC curve revealed that the performance of the uncorrected analysis was worse than random guess at some thresholds.<h4>Conclusions</h4>The ability of DSC permeability imaging to identify contrast enhancing tissue in stroke patients improved considerably when an ATC was applied. Using DSC permeability imaging in stroke patients without an ATC may lead to false identification of BBB disruption.Richard LeighShyian S JenDaniel D VarmaArgye E HillisPeter B BarkerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52656 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard Leigh Shyian S Jen Daniel D Varma Argye E Hillis Peter B Barker Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.
description	<h4>Purpose</h4>To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hypoperfusion.<h4>Materials and methods</h4>A technique described in brain tumor patients was adapted to incorporate a correction for delayed contrast delivery due to perfusion deficits. This technique was applied to the MRIs of 9 stroke patients known to have blood-brain barrier (BBB) disruption on T1 post contrast imaging. Regions of BBB damage were compared with normal tissue from the contralateral hemisphere. Receiver operating characteristic (ROC) analysis was performed to compare the detection of BBB damage before and after ATC.<h4>Results</h4>ATC improved the area under the curve (AUC) of the ROC from 0.53 to 0.70. The sensitivity improved from 0.51 to 0.67 and the specificity improved from 0.57 to 0.66. Visual inspection of the ROC curve revealed that the performance of the uncorrected analysis was worse than random guess at some thresholds.<h4>Conclusions</h4>The ability of DSC permeability imaging to identify contrast enhancing tissue in stroke patients improved considerably when an ATC was applied. Using DSC permeability imaging in stroke patients without an ATC may lead to false identification of BBB disruption.
format	article
author	Richard Leigh Shyian S Jen Daniel D Varma Argye E Hillis Peter B Barker
author_facet	Richard Leigh Shyian S Jen Daniel D Varma Argye E Hillis Peter B Barker
author_sort	Richard Leigh
title	Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.
title_short	Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.
title_full	Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.
title_fullStr	Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.
title_full_unstemmed	Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.
title_sort	arrival time correction for dynamic susceptibility contrast mr permeability imaging in stroke patients.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9088b9e82ff447dbb7e98318e6d98b68
work_keys_str_mv	AT richardleigh arrivaltimecorrectionfordynamicsusceptibilitycontrastmrpermeabilityimaginginstrokepatients AT shyiansjen arrivaltimecorrectionfordynamicsusceptibilitycontrastmrpermeabilityimaginginstrokepatients AT danieldvarma arrivaltimecorrectionfordynamicsusceptibilitycontrastmrpermeabilityimaginginstrokepatients AT argyeehillis arrivaltimecorrectionfordynamicsusceptibilitycontrastmrpermeabilityimaginginstrokepatients AT peterbbarker arrivaltimecorrectionfordynamicsusceptibilitycontrastmrpermeabilityimaginginstrokepatients
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Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients.

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