Nanobubbles for enhanced ultrasound imaging of tumors

Tinghui Yin1*, Ping Wang1*, Rongqin Zheng1, Bowen Zheng1, Du Cheng2, Xinling Zhang1, Xintao Shuai21Department of Medical Ultrasonic, Third Affiliated Hospital, 2PCFM Laboratory of the Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, People&a...

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Autores principales:	Yin T, Wang P, Zheng R, Zheng B, Cheng D, Zhang X, Shuai X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/908ad347cdb74a5da22b38ca5c4ce353
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spelling	oai:doaj.org-article:908ad347cdb74a5da22b38ca5c4ce3532021-12-02T05:09:45ZNanobubbles for enhanced ultrasound imaging of tumors1176-91141178-2013https://doaj.org/article/908ad347cdb74a5da22b38ca5c4ce3532012-02-01T00:00:00Zhttp://www.dovepress.com/nanobubbles-for-enhanced-ultrasound-imaging-of-tumors-a9324https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Tinghui Yin1, Ping Wang1, Rongqin Zheng1, Bowen Zheng1, Du Cheng2, Xinling Zhang1, Xintao Shuai21Department of Medical Ultrasonic, Third Affiliated Hospital, 2PCFM Laboratory of the Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, People&#39;s Republic of China*These authors contributed equally to this workAbstract: The fabrication and initial applications of nanobubbles (NBs) have shown promising results in recent years. A small particle size is a basic requirement for ultrasound contrast-enhanced agents that penetrate tumor blood vessel pores to allow for targeted imaging and therapy. However, the nanoscale size of the particles used has the disadvantage of weakening the imaging ability of clinical diagnostic ultrasound. In this work, we fabricated a lipid NBs contrast-enhanced ultrasound agent and evaluated its passive targeting ability in vivo. The results showed that the NBs were small (436.8 &plusmn; 5.7 nm), and in vitro ultrasound imaging suggested that the ultrasonic imaging ability is comparable to that of microbubbles (MBs). In vivo experiments confirmed the ability of NBs to passively target tumor tissues. The NBs remained in the tumor area for a longer period because they exhibited enhanced permeability and retention. Direct evidence was obtained by direct observation of red fluorescence-dyed NBs in tumor tissue using confocal laser scanning microscopy. We have demonstrated the ability to fabricate NBs that can be used for the in vivo contrast-enhanced imaging of tumor tissue and that have potential for drug/gene delivery.Keywords: phospholipids, ultrasound, contrast agent, tumor-targetedYin TWang PZheng RZheng BCheng DZhang XShuai XDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 895-904 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yin T Wang P Zheng R Zheng B Cheng D Zhang X Shuai X Nanobubbles for enhanced ultrasound imaging of tumors
description	Tinghui Yin1, Ping Wang1, Rongqin Zheng1, Bowen Zheng1, Du Cheng2, Xinling Zhang1, Xintao Shuai21Department of Medical Ultrasonic, Third Affiliated Hospital, 2PCFM Laboratory of the Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, People&#39;s Republic of China*These authors contributed equally to this workAbstract: The fabrication and initial applications of nanobubbles (NBs) have shown promising results in recent years. A small particle size is a basic requirement for ultrasound contrast-enhanced agents that penetrate tumor blood vessel pores to allow for targeted imaging and therapy. However, the nanoscale size of the particles used has the disadvantage of weakening the imaging ability of clinical diagnostic ultrasound. In this work, we fabricated a lipid NBs contrast-enhanced ultrasound agent and evaluated its passive targeting ability in vivo. The results showed that the NBs were small (436.8 &plusmn; 5.7 nm), and in vitro ultrasound imaging suggested that the ultrasonic imaging ability is comparable to that of microbubbles (MBs). In vivo experiments confirmed the ability of NBs to passively target tumor tissues. The NBs remained in the tumor area for a longer period because they exhibited enhanced permeability and retention. Direct evidence was obtained by direct observation of red fluorescence-dyed NBs in tumor tissue using confocal laser scanning microscopy. We have demonstrated the ability to fabricate NBs that can be used for the in vivo contrast-enhanced imaging of tumor tissue and that have potential for drug/gene delivery.Keywords: phospholipids, ultrasound, contrast agent, tumor-targeted
format	article
author	Yin T Wang P Zheng R Zheng B Cheng D Zhang X Shuai X
author_facet	Yin T Wang P Zheng R Zheng B Cheng D Zhang X Shuai X
author_sort	Yin T
title	Nanobubbles for enhanced ultrasound imaging of tumors
title_short	Nanobubbles for enhanced ultrasound imaging of tumors
title_full	Nanobubbles for enhanced ultrasound imaging of tumors
title_fullStr	Nanobubbles for enhanced ultrasound imaging of tumors
title_full_unstemmed	Nanobubbles for enhanced ultrasound imaging of tumors
title_sort	nanobubbles for enhanced ultrasound imaging of tumors
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/908ad347cdb74a5da22b38ca5c4ce353
work_keys_str_mv	AT yint nanobubblesforenhancedultrasoundimagingoftumors AT wangp nanobubblesforenhancedultrasoundimagingoftumors AT zhengr nanobubblesforenhancedultrasoundimagingoftumors AT zhengb nanobubblesforenhancedultrasoundimagingoftumors AT chengd nanobubblesforenhancedultrasoundimagingoftumors AT zhangx nanobubblesforenhancedultrasoundimagingoftumors AT shuaix nanobubblesforenhancedultrasoundimagingoftumors
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Nanobubbles for enhanced ultrasound imaging of tumors

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