SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar
Abstract The SARS-CoV-2 pandemic resulted in considerable morbidity and mortality as well as severe economic and societal disruptions. Despite scientific progress, true infection severity, factoring both diagnosed and undiagnosed infections, remains poorly understood. This study aimed to estimate SA...
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Nature Portfolio
2021
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oai:doaj.org-article:908b69b45efe41269208edacde7f765e2021-12-02T18:34:01ZSARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar10.1038/s41598-021-97606-82045-2322https://doaj.org/article/908b69b45efe41269208edacde7f765e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97606-8https://doaj.org/toc/2045-2322Abstract The SARS-CoV-2 pandemic resulted in considerable morbidity and mortality as well as severe economic and societal disruptions. Despite scientific progress, true infection severity, factoring both diagnosed and undiagnosed infections, remains poorly understood. This study aimed to estimate SARS-CoV-2 age-stratified and overall morbidity and mortality rates based on analysis of extensive epidemiological data for the pervasive epidemic in Qatar, a country where < 9% of the population are ≥ 50 years. We show that SARS-CoV-2 severity and fatality demonstrate a striking age dependence with low values for those aged < 50 years, but rapidly growing rates for those ≥ 50 years. Age dependence was particularly pronounced for infection criticality rate and infection fatality rate. With Qatar’s young population, overall SARS-CoV-2 severity and fatality were not high with < 4 infections in every 1000 being severe or critical and < 2 in every 10,000 being fatal. Only 13 infections in every 1000 received any hospitalization in acute-care-unit beds and < 2 in every 1000 were hospitalized in intensive-care-unit beds. However, we show that these rates would have been much higher if Qatar’s population had the demographic structure of Europe or the United States. Epidemic expansion in nations with young populations may lead to considerably lower disease burden than currently believed.Shaheen SeedatHiam ChemaitellyHoussein H. AyoubMonia MakhoulGhina R. MumtazZaina Al KanaaniAbdullatif Al KhalEinas Al KuwariAdeel A. ButtPeter CoyleAndrew JeremijenkoAnvar Hassan KaleeckalAli Nizar LatifRiyazuddin Mohammad ShaikHadi M. YassineMohamed G. Al KuwariHamad Eid Al RomaihiMohamed H. Al-ThaniRoberto BertolliniLaith J. Abu-RaddadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Shaheen Seedat Hiam Chemaitelly Houssein H. Ayoub Monia Makhoul Ghina R. Mumtaz Zaina Al Kanaani Abdullatif Al Khal Einas Al Kuwari Adeel A. Butt Peter Coyle Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Riyazuddin Mohammad Shaik Hadi M. Yassine Mohamed G. Al Kuwari Hamad Eid Al Romaihi Mohamed H. Al-Thani Roberto Bertollini Laith J. Abu-Raddad SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar |
| description |
Abstract The SARS-CoV-2 pandemic resulted in considerable morbidity and mortality as well as severe economic and societal disruptions. Despite scientific progress, true infection severity, factoring both diagnosed and undiagnosed infections, remains poorly understood. This study aimed to estimate SARS-CoV-2 age-stratified and overall morbidity and mortality rates based on analysis of extensive epidemiological data for the pervasive epidemic in Qatar, a country where < 9% of the population are ≥ 50 years. We show that SARS-CoV-2 severity and fatality demonstrate a striking age dependence with low values for those aged < 50 years, but rapidly growing rates for those ≥ 50 years. Age dependence was particularly pronounced for infection criticality rate and infection fatality rate. With Qatar’s young population, overall SARS-CoV-2 severity and fatality were not high with < 4 infections in every 1000 being severe or critical and < 2 in every 10,000 being fatal. Only 13 infections in every 1000 received any hospitalization in acute-care-unit beds and < 2 in every 1000 were hospitalized in intensive-care-unit beds. However, we show that these rates would have been much higher if Qatar’s population had the demographic structure of Europe or the United States. Epidemic expansion in nations with young populations may lead to considerably lower disease burden than currently believed. |
| format |
article |
| author |
Shaheen Seedat Hiam Chemaitelly Houssein H. Ayoub Monia Makhoul Ghina R. Mumtaz Zaina Al Kanaani Abdullatif Al Khal Einas Al Kuwari Adeel A. Butt Peter Coyle Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Riyazuddin Mohammad Shaik Hadi M. Yassine Mohamed G. Al Kuwari Hamad Eid Al Romaihi Mohamed H. Al-Thani Roberto Bertollini Laith J. Abu-Raddad |
| author_facet |
Shaheen Seedat Hiam Chemaitelly Houssein H. Ayoub Monia Makhoul Ghina R. Mumtaz Zaina Al Kanaani Abdullatif Al Khal Einas Al Kuwari Adeel A. Butt Peter Coyle Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Riyazuddin Mohammad Shaik Hadi M. Yassine Mohamed G. Al Kuwari Hamad Eid Al Romaihi Mohamed H. Al-Thani Roberto Bertollini Laith J. Abu-Raddad |
| author_sort |
Shaheen Seedat |
| title |
SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar |
| title_short |
SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar |
| title_full |
SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar |
| title_fullStr |
SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar |
| title_full_unstemmed |
SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar |
| title_sort |
sars-cov-2 infection hospitalization, severity, criticality, and fatality rates in qatar |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/908b69b45efe41269208edacde7f765e |
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