Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations

Abstract Droplet-based transport driven by surface tension has been explored as an automated pumping source for several biomedical applications. This paper presented a simple and fast superhydrophobic modify and patterning approach to fabricate various open-surface platforms to manipulate droplets t...

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Autores principales:	Wan-Hsuan Lin, Chien-Wei Chen, Sheng-Hang Wang, Bor-Ran Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/908f9d376fdd4bb493e513d3323b48bf
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spelling	oai:doaj.org-article:908f9d376fdd4bb493e513d3323b48bf2021-12-02T16:17:22ZRapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations10.1038/s41598-021-94484-y2045-2322https://doaj.org/article/908f9d376fdd4bb493e513d3323b48bf2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94484-yhttps://doaj.org/toc/2045-2322Abstract Droplet-based transport driven by surface tension has been explored as an automated pumping source for several biomedical applications. This paper presented a simple and fast superhydrophobic modify and patterning approach to fabricate various open-surface platforms to manipulate droplets to achieve transport, mixing, concentration, and rebounding control. Several commercial reagents were tested in our approach, and the Glaco reagent was selected to create a superhydrophobic layer; laser cutters are utilized to scan on these superhydrophobic surface to create gradient hydrophilic micro-patterns. Implementing back-and-forth vibrations on the predetermined parallel patterns, droplets can be transported and mixed successfully. Colorimetry of horseradish peroxidase (HRP) mixing with substrates also reduced the reaction time by more than 5-times with the help of superhydrophobic patterned chips. Besides, patterned superhydrophobic chips can significantly improve the sensitivity of colorimetric glucose-sensing by more than 10 times. Moreover, all bioassays were distributed homogeneously within the region of hydrophilic micropatterns without the coffee-ring effect. In addition, to discuss further applications of the surface wettability, the way of controlling the droplet impacting and rebounding phenomenon was also demonstrated. This work reports a rapid approach to modify and patterning superhydrophobic films to perform droplet-based manipulations with a lower technical barrier, higher efficiency, and easier operation. It holds the potential to broaden the applications of open microfluidics in the future.Wan-Hsuan LinChien-Wei ChenSheng-Hang WangBor-Ran LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wan-Hsuan Lin Chien-Wei Chen Sheng-Hang Wang Bor-Ran Li Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
description	Abstract Droplet-based transport driven by surface tension has been explored as an automated pumping source for several biomedical applications. This paper presented a simple and fast superhydrophobic modify and patterning approach to fabricate various open-surface platforms to manipulate droplets to achieve transport, mixing, concentration, and rebounding control. Several commercial reagents were tested in our approach, and the Glaco reagent was selected to create a superhydrophobic layer; laser cutters are utilized to scan on these superhydrophobic surface to create gradient hydrophilic micro-patterns. Implementing back-and-forth vibrations on the predetermined parallel patterns, droplets can be transported and mixed successfully. Colorimetry of horseradish peroxidase (HRP) mixing with substrates also reduced the reaction time by more than 5-times with the help of superhydrophobic patterned chips. Besides, patterned superhydrophobic chips can significantly improve the sensitivity of colorimetric glucose-sensing by more than 10 times. Moreover, all bioassays were distributed homogeneously within the region of hydrophilic micropatterns without the coffee-ring effect. In addition, to discuss further applications of the surface wettability, the way of controlling the droplet impacting and rebounding phenomenon was also demonstrated. This work reports a rapid approach to modify and patterning superhydrophobic films to perform droplet-based manipulations with a lower technical barrier, higher efficiency, and easier operation. It holds the potential to broaden the applications of open microfluidics in the future.
format	article
author	Wan-Hsuan Lin Chien-Wei Chen Sheng-Hang Wang Bor-Ran Li
author_facet	Wan-Hsuan Lin Chien-Wei Chen Sheng-Hang Wang Bor-Ran Li
author_sort	Wan-Hsuan Lin
title	Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
title_short	Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
title_full	Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
title_fullStr	Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
title_full_unstemmed	Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
title_sort	rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/908f9d376fdd4bb493e513d3323b48bf
work_keys_str_mv	AT wanhsuanlin rapidconstructsuperhydrophobicmicrocracksontheopensurfaceplatformfordropletmanipulations AT chienweichen rapidconstructsuperhydrophobicmicrocracksontheopensurfaceplatformfordropletmanipulations AT shenghangwang rapidconstructsuperhydrophobicmicrocracksontheopensurfaceplatformfordropletmanipulations AT borranli rapidconstructsuperhydrophobicmicrocracksontheopensurfaceplatformfordropletmanipulations
_version_	1718384243823869952

Rapid construct superhydrophobic microcracks on the open-surface platform for droplet manipulations

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