Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis

Abstract Background The present study provides a snapshot of Italian patients with peritoneal metastasis from gastric cancer treated by surgery in Italian centers belonging to the Italian Research Group on Gastric Cancer. Prognostic factors affecting survival in such cohort of patients were evaluate...

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Autores principales:	Luigina Graziosi, Elisabetta Marino, Maria Bencivenga, Alessia D’Ignazio, Leonardo Solaini, Silvia Ministrini, Michela Caprioli, Michele Sacco, Daniele Marrelli, Gianni Mura, Maurizio Degiuli, Paolo Morgagni, Guido Alberto Massimo Tiberio, Giovanni De Manzoni, Franco Roviello, Annibale Donini
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Gastric cancer Peritoneal carcinomatosis Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/90919a9b596149e895affa76b44be0e7
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spelling	oai:doaj.org-article:90919a9b596149e895affa76b44be0e72021-11-28T12:30:39ZLooking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis10.1186/s12957-021-02442-91477-7819https://doaj.org/article/90919a9b596149e895affa76b44be0e72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12957-021-02442-9https://doaj.org/toc/1477-7819Abstract Background The present study provides a snapshot of Italian patients with peritoneal metastasis from gastric cancer treated by surgery in Italian centers belonging to the Italian Research Group on Gastric Cancer. Prognostic factors affecting survival in such cohort of patients were evaluated with the final aim to identify patients who may benefit from radical intent surgery. Methods It is a multicentric retrospective study based on a prospectively collected database including demographics, clinical, surgical, pathological, and follow-up data of patients with gastric cancer and synchronous macroscopic peritoneal metastases. Patients were surgically treated from January 2005 to January 2017. We focused on patients with macroscopic peritoneal carcinomatosis (PC) treated with upfront surgery in order to provide homogeneous evidences. Results Our results show that patients with peritoneal carcinomatosis cannot be considered all lost. Strictly selected cases (R0/R1 and P1 patients) could benefit from an aggressive surgical approach performing an extended lymphadenectomy and HIPEC treatment. Conclusion The main result of the study is that GC patients with limited peritoneal involvement can have a survival benefit from a surgery with “radical oncological intent”, that means extended lymphadenectomy and R0 resection. The retrospective nature of this study is an important bias, and for this reason, we have started a prospective multicentric study including Italian stage IV patients that hopefully will give us more answers.Luigina GraziosiElisabetta MarinoMaria BencivengaAlessia D’IgnazioLeonardo SolainiSilvia MinistriniMichela CaprioliMichele SaccoDaniele MarrelliGianni MuraMaurizio DegiuliPaolo MorgagniGuido Alberto Massimo TiberioGiovanni De ManzoniFranco RovielloAnnibale DoniniBMCarticleGastric cancerPeritoneal carcinomatosisSurgerySurgeryRD1-811Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENWorld Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gastric cancer Peritoneal carcinomatosis Surgery Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Gastric cancer Peritoneal carcinomatosis Surgery Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Luigina Graziosi Elisabetta Marino Maria Bencivenga Alessia D’Ignazio Leonardo Solaini Silvia Ministrini Michela Caprioli Michele Sacco Daniele Marrelli Gianni Mura Maurizio Degiuli Paolo Morgagni Guido Alberto Massimo Tiberio Giovanni De Manzoni Franco Roviello Annibale Donini Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis
description	Abstract Background The present study provides a snapshot of Italian patients with peritoneal metastasis from gastric cancer treated by surgery in Italian centers belonging to the Italian Research Group on Gastric Cancer. Prognostic factors affecting survival in such cohort of patients were evaluated with the final aim to identify patients who may benefit from radical intent surgery. Methods It is a multicentric retrospective study based on a prospectively collected database including demographics, clinical, surgical, pathological, and follow-up data of patients with gastric cancer and synchronous macroscopic peritoneal metastases. Patients were surgically treated from January 2005 to January 2017. We focused on patients with macroscopic peritoneal carcinomatosis (PC) treated with upfront surgery in order to provide homogeneous evidences. Results Our results show that patients with peritoneal carcinomatosis cannot be considered all lost. Strictly selected cases (R0/R1 and P1 patients) could benefit from an aggressive surgical approach performing an extended lymphadenectomy and HIPEC treatment. Conclusion The main result of the study is that GC patients with limited peritoneal involvement can have a survival benefit from a surgery with “radical oncological intent”, that means extended lymphadenectomy and R0 resection. The retrospective nature of this study is an important bias, and for this reason, we have started a prospective multicentric study including Italian stage IV patients that hopefully will give us more answers.
format	article
author	Luigina Graziosi Elisabetta Marino Maria Bencivenga Alessia D’Ignazio Leonardo Solaini Silvia Ministrini Michela Caprioli Michele Sacco Daniele Marrelli Gianni Mura Maurizio Degiuli Paolo Morgagni Guido Alberto Massimo Tiberio Giovanni De Manzoni Franco Roviello Annibale Donini
author_facet	Luigina Graziosi Elisabetta Marino Maria Bencivenga Alessia D’Ignazio Leonardo Solaini Silvia Ministrini Michela Caprioli Michele Sacco Daniele Marrelli Gianni Mura Maurizio Degiuli Paolo Morgagni Guido Alberto Massimo Tiberio Giovanni De Manzoni Franco Roviello Annibale Donini
author_sort	Luigina Graziosi
title	Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis
title_short	Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis
title_full	Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis
title_fullStr	Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis
title_full_unstemmed	Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis
title_sort	looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an italian multicenter gastric cancer research group’s analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/90919a9b596149e895affa76b44be0e7
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Looking for a strategy in treating peritoneal gastric cancer carcinomatosis: an Italian multicenter Gastric Cancer Research group’s analysis

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