Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
Multiple sclerosis: Sequence variants discovered by meta-analysis informed by genetic correlation Combining studies and comparing across diseases turned up 14 novel gene variants linked to multiple sclerosis (MS). A team led by Kári Stefánsson and Ingileif Jónsdóttir from deCODE genetics in Reykjaví...
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Nature Portfolio
2017
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oai:doaj.org-article:9096113a85cf464487746a5332bdc34b2021-12-02T16:08:59ZFourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations10.1038/s41525-017-0027-22056-7944https://doaj.org/article/9096113a85cf464487746a5332bdc34b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41525-017-0027-2https://doaj.org/toc/2056-7944Multiple sclerosis: Sequence variants discovered by meta-analysis informed by genetic correlation Combining studies and comparing across diseases turned up 14 novel gene variants linked to multiple sclerosis (MS). A team led by Kári Stefánsson and Ingileif Jónsdóttir from deCODE genetics in Reykjavík, Iceland, amalgamated data from a large international study of MS with three smaller ones from Sweden, Norway and Iceland. They conducted a meta-analysis on the combined data set — which encompassed around 21,000 MS patients and 372,000 population controls — and uncovered seven new genetic risk variants linked to MS. The researchers then compared the genetic overlap between various autoimmune diseases in the Icelandic cohort, and documented a close relationship between MS and primary biliary cirrhosis (PBC). They looked more closely at variants linked to PBC, and found that seven also increased the risk for MS, bringing the tally of novel gene variants up to fourteen.Sigurgeir OlafssonPernilla StridhSteffan Daniël BosAndres IngasonJack EuesdenPatrick SulemGudmar ThorleifssonOmar GustafssonAri JohannessonArni J. GeirssonArni V. ThorssonBardur SigurgeirssonBjorn Runar LudvikssonElias OlafssonHelga KristjansdottirJon G. JonassonJon Hjaltalin OlafssonKjartan B. OrvarRafn BenediktssonRagnar BjarnasonSjofn KristjansdottirThorarinn GislasonTrausti ValdimarssonEvgenia MikaelsdottirSnaevar SigurdssonStefan JonssonThorunn RafnarDag AarslandSrdjan DjurovicTormod FladbyGun Peggy KnudsenElisabeth G. CeliusKjell-Morten MyhrGerdur GrondalKristjan SteinssonHelgi ValdimarssonSigurdur BjornssonUnnur S. BjornsdottirEinar S BjornssonBjorn NilssonOle A. AndreassenLars AlfredssonJan HillertIngrid Skelton KockumGisli MassonUnnur ThorsteinsdottirDaniel F. GudbjartssonHreinn StefanssonHaukur HjaltasonHanne F. HarboTomas OlssonIngileif JonsdottirKari StefanssonNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-12 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Medicine R Genetics QH426-470 |
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Medicine R Genetics QH426-470 Sigurgeir Olafsson Pernilla Stridh Steffan Daniël Bos Andres Ingason Jack Euesden Patrick Sulem Gudmar Thorleifsson Omar Gustafsson Ari Johannesson Arni J. Geirsson Arni V. Thorsson Bardur Sigurgeirsson Bjorn Runar Ludviksson Elias Olafsson Helga Kristjansdottir Jon G. Jonasson Jon Hjaltalin Olafsson Kjartan B. Orvar Rafn Benediktsson Ragnar Bjarnason Sjofn Kristjansdottir Thorarinn Gislason Trausti Valdimarsson Evgenia Mikaelsdottir Snaevar Sigurdsson Stefan Jonsson Thorunn Rafnar Dag Aarsland Srdjan Djurovic Tormod Fladby Gun Peggy Knudsen Elisabeth G. Celius Kjell-Morten Myhr Gerdur Grondal Kristjan Steinsson Helgi Valdimarsson Sigurdur Bjornsson Unnur S. Bjornsdottir Einar S Bjornsson Bjorn Nilsson Ole A. Andreassen Lars Alfredsson Jan Hillert Ingrid Skelton Kockum Gisli Masson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Hreinn Stefansson Haukur Hjaltason Hanne F. Harbo Tomas Olsson Ingileif Jonsdottir Kari Stefansson Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| description |
Multiple sclerosis: Sequence variants discovered by meta-analysis informed by genetic correlation Combining studies and comparing across diseases turned up 14 novel gene variants linked to multiple sclerosis (MS). A team led by Kári Stefánsson and Ingileif Jónsdóttir from deCODE genetics in Reykjavík, Iceland, amalgamated data from a large international study of MS with three smaller ones from Sweden, Norway and Iceland. They conducted a meta-analysis on the combined data set — which encompassed around 21,000 MS patients and 372,000 population controls — and uncovered seven new genetic risk variants linked to MS. The researchers then compared the genetic overlap between various autoimmune diseases in the Icelandic cohort, and documented a close relationship between MS and primary biliary cirrhosis (PBC). They looked more closely at variants linked to PBC, and found that seven also increased the risk for MS, bringing the tally of novel gene variants up to fourteen. |
| format |
article |
| author |
Sigurgeir Olafsson Pernilla Stridh Steffan Daniël Bos Andres Ingason Jack Euesden Patrick Sulem Gudmar Thorleifsson Omar Gustafsson Ari Johannesson Arni J. Geirsson Arni V. Thorsson Bardur Sigurgeirsson Bjorn Runar Ludviksson Elias Olafsson Helga Kristjansdottir Jon G. Jonasson Jon Hjaltalin Olafsson Kjartan B. Orvar Rafn Benediktsson Ragnar Bjarnason Sjofn Kristjansdottir Thorarinn Gislason Trausti Valdimarsson Evgenia Mikaelsdottir Snaevar Sigurdsson Stefan Jonsson Thorunn Rafnar Dag Aarsland Srdjan Djurovic Tormod Fladby Gun Peggy Knudsen Elisabeth G. Celius Kjell-Morten Myhr Gerdur Grondal Kristjan Steinsson Helgi Valdimarsson Sigurdur Bjornsson Unnur S. Bjornsdottir Einar S Bjornsson Bjorn Nilsson Ole A. Andreassen Lars Alfredsson Jan Hillert Ingrid Skelton Kockum Gisli Masson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Hreinn Stefansson Haukur Hjaltason Hanne F. Harbo Tomas Olsson Ingileif Jonsdottir Kari Stefansson |
| author_facet |
Sigurgeir Olafsson Pernilla Stridh Steffan Daniël Bos Andres Ingason Jack Euesden Patrick Sulem Gudmar Thorleifsson Omar Gustafsson Ari Johannesson Arni J. Geirsson Arni V. Thorsson Bardur Sigurgeirsson Bjorn Runar Ludviksson Elias Olafsson Helga Kristjansdottir Jon G. Jonasson Jon Hjaltalin Olafsson Kjartan B. Orvar Rafn Benediktsson Ragnar Bjarnason Sjofn Kristjansdottir Thorarinn Gislason Trausti Valdimarsson Evgenia Mikaelsdottir Snaevar Sigurdsson Stefan Jonsson Thorunn Rafnar Dag Aarsland Srdjan Djurovic Tormod Fladby Gun Peggy Knudsen Elisabeth G. Celius Kjell-Morten Myhr Gerdur Grondal Kristjan Steinsson Helgi Valdimarsson Sigurdur Bjornsson Unnur S. Bjornsdottir Einar S Bjornsson Bjorn Nilsson Ole A. Andreassen Lars Alfredsson Jan Hillert Ingrid Skelton Kockum Gisli Masson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Hreinn Stefansson Haukur Hjaltason Hanne F. Harbo Tomas Olsson Ingileif Jonsdottir Kari Stefansson |
| author_sort |
Sigurgeir Olafsson |
| title |
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| title_short |
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| title_full |
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| title_fullStr |
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| title_full_unstemmed |
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| title_sort |
fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/9096113a85cf464487746a5332bdc34b |
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