Age-related changes in diffuse optical tomography sensitivity profiles in infancy.

Diffuse optical tomography uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the location that generates the hemodynamic signal requires accurate descriptions of diffuse optical tomography sensitivity to the underlying cortic...

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Autores principales:	Xiaoxue Fu, John E Richards
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9097244334284fafa8a79556aca1fdaa
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spelling	oai:doaj.org-article:9097244334284fafa8a79556aca1fdaa2021-12-02T20:03:53ZAge-related changes in diffuse optical tomography sensitivity profiles in infancy.1932-620310.1371/journal.pone.0252036https://doaj.org/article/9097244334284fafa8a79556aca1fdaa2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252036https://doaj.org/toc/1932-6203Diffuse optical tomography uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the location that generates the hemodynamic signal requires accurate descriptions of diffuse optical tomography sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development. The present study used photon propagation simulation methods to examine diffuse optical tomography sensitivity profiles in realistic head models among infants ranging from 2 weeks to 24 months with narrow age bins, children (4 and 12 years) and adults (20 to 24 years). The sensitivity profiles changed systematically with the source-detector separation distance. The peak of the sensitivity function in the head was largest at the smallest separation distance and decreased as separation distance increased. The fluence value dissipated more quickly with sampling depth at the shorter source-detector separations than the longer separation distances. There were age-related differences in the shape and variance of sensitivity profiles across a wide range of source-detector separation distances. Our findings have important implications in the design of sensor placement and diffuse optical tomography image reconstruction in (functional) near-infrared light spectroscopy research. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone near-infrared light spectroscopy data in infants.Xiaoxue FuJohn E RichardsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252036 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoxue Fu John E Richards Age-related changes in diffuse optical tomography sensitivity profiles in infancy.
description	Diffuse optical tomography uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the location that generates the hemodynamic signal requires accurate descriptions of diffuse optical tomography sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development. The present study used photon propagation simulation methods to examine diffuse optical tomography sensitivity profiles in realistic head models among infants ranging from 2 weeks to 24 months with narrow age bins, children (4 and 12 years) and adults (20 to 24 years). The sensitivity profiles changed systematically with the source-detector separation distance. The peak of the sensitivity function in the head was largest at the smallest separation distance and decreased as separation distance increased. The fluence value dissipated more quickly with sampling depth at the shorter source-detector separations than the longer separation distances. There were age-related differences in the shape and variance of sensitivity profiles across a wide range of source-detector separation distances. Our findings have important implications in the design of sensor placement and diffuse optical tomography image reconstruction in (functional) near-infrared light spectroscopy research. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone near-infrared light spectroscopy data in infants.
format	article
author	Xiaoxue Fu John E Richards
author_facet	Xiaoxue Fu John E Richards
author_sort	Xiaoxue Fu
title	Age-related changes in diffuse optical tomography sensitivity profiles in infancy.
title_short	Age-related changes in diffuse optical tomography sensitivity profiles in infancy.
title_full	Age-related changes in diffuse optical tomography sensitivity profiles in infancy.
title_fullStr	Age-related changes in diffuse optical tomography sensitivity profiles in infancy.
title_full_unstemmed	Age-related changes in diffuse optical tomography sensitivity profiles in infancy.
title_sort	age-related changes in diffuse optical tomography sensitivity profiles in infancy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9097244334284fafa8a79556aca1fdaa
work_keys_str_mv	AT xiaoxuefu agerelatedchangesindiffuseopticaltomographysensitivityprofilesininfancy AT johnerichards agerelatedchangesindiffuseopticaltomographysensitivityprofilesininfancy
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Age-related changes in diffuse optical tomography sensitivity profiles in infancy.

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