Ex vivo distribution of gold nanoparticles in choroidal melanoma

Mozhgan Rezaei Kanavi,1 Somayeh Asadi,1,2 Hamid Ahmadieh2 1Ocular Tissue Engineering Research Center, 2Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranStudies on combined radiotherapy and nanoparticles (NPs) have shown that a greater therapeutic ratio can be...

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Autores principales:	Kanavi MR, Asadi S, Ahmadieh H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Ex-vivo distribution GNPs eye melanoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/90978c85a31a489fadbfbd46ed461eb7
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spelling	oai:doaj.org-article:90978c85a31a489fadbfbd46ed461eb72021-12-02T00:35:52ZEx vivo distribution of gold nanoparticles in choroidal melanoma1178-2013https://doaj.org/article/90978c85a31a489fadbfbd46ed461eb72017-11-01T00:00:00Zhttps://www.dovepress.com/ex-vivo-distribution-of-gold-nanoparticles-in-choroidal-melanoma-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mozhgan Rezaei Kanavi,1 Somayeh Asadi,1,2 Hamid Ahmadieh2 1Ocular Tissue Engineering Research Center, 2Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranStudies on combined radiotherapy and nanoparticles (NPs) have shown that a greater therapeutic ratio can be achieved using gold nanoparticles (GNPs) as radiosensitizing agents within the tumor.1 Recent Monte Carlo studies demonstrated that GNPs enhance the absorbed dose by choroidal melanoma during brachytherapy with sources such as 103Pd and 125I.2 Given that the energy range of these sources is low, NPs with high atomic number can be suitable to yield a higher absorbed dose when used alongside the mentioned sources.3 Although it has been a long time since the merit and priority of using NPs in treating cancer by low-energy sources has been studied, regarding eye cancers a major concern has been the way these NPs would be spread in the ocular tissues. A principal question is the form and method by which the NPs disperse within the intraocular tumor after intralesional injection. Will the NPs be also absorbed by the nearby healthy tissues?Kanavi MRAsadi SAhmadieh HDove Medical PressarticleEx-vivodistributionGNPseye melanomaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8527-8529 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ex-vivo distribution GNPs eye melanoma Medicine (General) R5-920
spellingShingle	Ex-vivo distribution GNPs eye melanoma Medicine (General) R5-920 Kanavi MR Asadi S Ahmadieh H Ex vivo distribution of gold nanoparticles in choroidal melanoma
description	Mozhgan Rezaei Kanavi,1 Somayeh Asadi,1,2 Hamid Ahmadieh2 1Ocular Tissue Engineering Research Center, 2Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranStudies on combined radiotherapy and nanoparticles (NPs) have shown that a greater therapeutic ratio can be achieved using gold nanoparticles (GNPs) as radiosensitizing agents within the tumor.1 Recent Monte Carlo studies demonstrated that GNPs enhance the absorbed dose by choroidal melanoma during brachytherapy with sources such as 103Pd and 125I.2 Given that the energy range of these sources is low, NPs with high atomic number can be suitable to yield a higher absorbed dose when used alongside the mentioned sources.3 Although it has been a long time since the merit and priority of using NPs in treating cancer by low-energy sources has been studied, regarding eye cancers a major concern has been the way these NPs would be spread in the ocular tissues. A principal question is the form and method by which the NPs disperse within the intraocular tumor after intralesional injection. Will the NPs be also absorbed by the nearby healthy tissues?
format	article
author	Kanavi MR Asadi S Ahmadieh H
author_facet	Kanavi MR Asadi S Ahmadieh H
author_sort	Kanavi MR
title	Ex vivo distribution of gold nanoparticles in choroidal melanoma
title_short	Ex vivo distribution of gold nanoparticles in choroidal melanoma
title_full	Ex vivo distribution of gold nanoparticles in choroidal melanoma
title_fullStr	Ex vivo distribution of gold nanoparticles in choroidal melanoma
title_full_unstemmed	Ex vivo distribution of gold nanoparticles in choroidal melanoma
title_sort	ex vivo distribution of gold nanoparticles in choroidal melanoma
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/90978c85a31a489fadbfbd46ed461eb7
work_keys_str_mv	AT kanavimr exvivodistributionofgoldnanoparticlesinchoroidalmelanoma AT asadis exvivodistributionofgoldnanoparticlesinchoroidalmelanoma AT ahmadiehh exvivodistributionofgoldnanoparticlesinchoroidalmelanoma
_version_	1718403631109111808

Ex vivo distribution of gold nanoparticles in choroidal melanoma

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