Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model

Coragen is an insecticide that stimulates calcium release from intracellular stores of muscle cells causing death to sensitive species. The present study aimed to evaluate the bone toxic effect of Coragen and the potential therapeutic effect of cow milk, yogurt, and soft cheese in rats. Toxicity was...

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Autores principales:	Abdel-Mobdy Ahmed E., Abdel-Mobdy Yasmen E., Mabrok Hoda B.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	osteoporosis coragen cow milk yogurt soft cheese Agriculture S Agriculture (General) S1-972
Acceso en línea:	https://doaj.org/article/90a51da224254edbab23591315344d38
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spelling	oai:doaj.org-article:90a51da224254edbab23591315344d382021-12-05T14:10:59ZCow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model2391-953110.1515/opag-2021-0033https://doaj.org/article/90a51da224254edbab23591315344d382021-08-01T00:00:00Zhttps://doi.org/10.1515/opag-2021-0033https://doaj.org/toc/2391-9531Coragen is an insecticide that stimulates calcium release from intracellular stores of muscle cells causing death to sensitive species. The present study aimed to evaluate the bone toxic effect of Coragen and the potential therapeutic effect of cow milk, yogurt, and soft cheese in rats. Toxicity was induced by Coragen administration with different doses of 1/20 or 1/40 LD50 in rats. Groups of rats (n = 6) were treated with either 5 g milk, 5 g yogurt, or 1.5 g cheese. Coragen administration elevated alkaline and acid phosphatases activity and reduced the calcium and phosphorus level in urine and serum of rats administered with Coragen. Femur and tibia length, thickness, weight, and breaking force were decreased by Coragen administration and femur Ca and P contents as well. Bone mineral area (BMA), bone mineral content (BMC), bone mineral density (BMD), protein profile (total, albumin, and globulin), and antioxidant system (TAC, GSH, GPX, GST, and SOD) were decreased by Coragen. All these parameters were improved on the treatment with milk and milk products. The results showed that yogurt treatment was significantly superior to the other treatments in increasing BMD (27%), breaking force (9%), femur Ca (41%), serum Ca (14%), and serum P (16%) and in reducing acid phosphatases (14%) and urine Ca and P by 8 and 10%, respectively. It can be concluded that the treatment with milk and milk products may provide treatment against osteoporosis and toxicity caused by Coragen.Abdel-Mobdy Ahmed E.Abdel-Mobdy Yasmen E.Mabrok Hoda B.De Gruyterarticleosteoporosiscoragencow milkyogurtsoft cheeseAgricultureSAgriculture (General)S1-972ENOpen Agriculture, Vol 6, Iss 1, Pp 498-510 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis coragen cow milk yogurt soft cheese Agriculture S Agriculture (General) S1-972
spellingShingle	osteoporosis coragen cow milk yogurt soft cheese Agriculture S Agriculture (General) S1-972 Abdel-Mobdy Ahmed E. Abdel-Mobdy Yasmen E. Mabrok Hoda B. Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model
description	Coragen is an insecticide that stimulates calcium release from intracellular stores of muscle cells causing death to sensitive species. The present study aimed to evaluate the bone toxic effect of Coragen and the potential therapeutic effect of cow milk, yogurt, and soft cheese in rats. Toxicity was induced by Coragen administration with different doses of 1/20 or 1/40 LD50 in rats. Groups of rats (n = 6) were treated with either 5 g milk, 5 g yogurt, or 1.5 g cheese. Coragen administration elevated alkaline and acid phosphatases activity and reduced the calcium and phosphorus level in urine and serum of rats administered with Coragen. Femur and tibia length, thickness, weight, and breaking force were decreased by Coragen administration and femur Ca and P contents as well. Bone mineral area (BMA), bone mineral content (BMC), bone mineral density (BMD), protein profile (total, albumin, and globulin), and antioxidant system (TAC, GSH, GPX, GST, and SOD) were decreased by Coragen. All these parameters were improved on the treatment with milk and milk products. The results showed that yogurt treatment was significantly superior to the other treatments in increasing BMD (27%), breaking force (9%), femur Ca (41%), serum Ca (14%), and serum P (16%) and in reducing acid phosphatases (14%) and urine Ca and P by 8 and 10%, respectively. It can be concluded that the treatment with milk and milk products may provide treatment against osteoporosis and toxicity caused by Coragen.
format	article
author	Abdel-Mobdy Ahmed E. Abdel-Mobdy Yasmen E. Mabrok Hoda B.
author_facet	Abdel-Mobdy Ahmed E. Abdel-Mobdy Yasmen E. Mabrok Hoda B.
author_sort	Abdel-Mobdy Ahmed E.
title	Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model
title_short	Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model
title_full	Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model
title_fullStr	Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model
title_full_unstemmed	Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model
title_sort	cow milk and its dairy products ameliorate bone toxicity in the coragen-induced rat model
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/90a51da224254edbab23591315344d38
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Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model

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